Tramadol N-oxide material, enantiomers and compositions thereof, and their use
Patent 5223541 Issued on June 29, 1993. Estimated Expiration Date: 
September 13, 2011. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
September 13, 2011. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References3652589 InventorsApplicationNo. 759259 filed on 09/13/1991US Classes:514/644, Amine oxides514/850, Antitussive514/867, DIARRHEA564/299Benzene ring containingExaminersPrimary: Raymond, Richard L.Assistant: O'Sullivan, P. Attorney, Agent or FirmInternational ClassesA61K 031/13C07C 291/00 AbstractThis invention relates to a tramadol N-oxide material, enantiomers and compositions thereof and their use. The tramadol N-oxide material and compositions thereof are pharmacologically useful in treating pain, diarrhea and tussive conditions. The tramadol N-oxide is also subject to less side-effects as compared to pure opiate based compositions, such as abuse liability, tolerance, constipation and respiratory depression. Furthermore, the tramadol N-oxide material when administered orally exhibits analgesia for a longer duration than an equi-analgesic amount of tramadol. |
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