Monoclonal antibodies reactive with defined regions of the T-cell antigen receptor

Patent 5223426 Issued on June 29, 1993. Estimated Expiration Date:

June 29, 2010. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Abstract Claims Description Full Text

Patent References

Monoclonal antibodies that recognize human T cells
Patent #: 4550086
Issued on: 10/29/1985
Inventor: Reinherz , et al.

Assay systems for detecting cell-free T cell antigen receptor related molecules and the clinical utilities of the assays
Patent #: 4845026
Issued on: 07/04/1989
Inventor: Kung , et al.

Diagnostic reagents based on unique sequences within the variable region of the T cell receptor and uses thereof
Patent #: 4886743
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Inventor: Hood, et al.

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Issued on: 05/08/1990
Inventor: Mak

Inventors

Assignee

T Cell Sciences, Inc.

Application

No. 449692 filed on 12/11/1989

US Classes:

435/331, Immunoglobulin or antibody binds a specifically identified amino acid sequence424/144.1, Receptor integral to or derived from a lymphocytic or lymphocytic-like cell (e.g., NK cell, etc.)424/154.1, T lymphocytic cell (e.g., T cell, thymocyte, etc.)530/387.1, Immunoglobulin, antibody, or fragment thereof, other than immunoglobulin antibody, or fragment thereof that is conjugated or absorbed530/387.9, Binds specifically-identified amino acid sequence530/388.22, Binds receptor (e.g., transferrin receptor, Fc receptor, dihydropyridine receptor, IL-2 receptor, etc.)530/388.75Binds T-lymphocytic cell or component or product thereof (e.g., T cell, thymocyte, T-lineage bone marrow cell, T-lymphoblastoid cell, T-lineage acute lymphoblastic leukemia cell, T-lymphocytic cell-surface antigen, etc.)

Examiners

Primary: Nucker, Christine M.
Assistant: Sidberry, Hazel F.

Attorney, Agent or Firm

Pennie & Edmonds

Foreign Patent References

0180171A2 EP. 10/13/1985
0180878A2 EP. 10/13/1985
0200350A2 EP. 03/13/1986
0289252A2 EP. 11/13/1988
0340109A2 EP. 04/13/1989
0250333A1 DE. 10/13/1987
61-254529 JP. 11/13/1986
63-030500 JP. 02/13/1988
2197323A GB. 05/13/1988
WO84/02848 WO. 08/13/1984
WO88/00209 WO. 01/13/1988
WO89/02899 WO. 04/13/1989
WO89/05309 WO. 06/13/1989

International Classes

A61K 039/00
A61K 035/16

Abstract

The present invention relates to monoclonal antibodies which recognize defined regions of the T-cell receptor (TCR). In a specific embodiment, the invention provides monoclonal antibodies which are reactive with a constant region of the alpha chain of the TCR. In particular embodiments, the invention relates to two monoclonal antibodies, termed 򳇱 and 򳇲, which react with two different epitopes on the framework region of the ଱ monomer of the TCR molecule. In another specific embodiment, the invention is directed to monoclonal antibodies reactive with a variable region of the beta chain of the TCR. In particular, the invention provides two monoclonal antibodies, termed W112 and 2D1, which react with ଲ chain variable regions V댥.3 and V댨.1, respectively. In another specific embodiment, the invention is directed to monoclonal antibodies reactive with a variable region of the delta chain of the TCR. In particular, the invention provides monoclonal antibody δTCS1, isotype IgG2a. The monoclonal antibodies of the invention have value in diagnosis and therapy and are useful tools for study of the immune system.

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