Poly(alkylene oxide) amino acid copolymers and drug carriers and charged copolymers based thereon
July 5, 2011. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesNon-immunogenic polypeptides Peptide macromolecular complexes Induction of immunological tolerance Drug delivery by polymeric carriers Bifunctional linker Anhydrous enhanced coupling of proteins Biodegradable polymeric drug delivery system with adjuvant activity Biodegradable synthesis polypeptide and its therapeutic use Conjugates in which a monovalent carboxylic ionophore is associated by means of a covalent bond with a macromolecule, their use as immunotoxin potentiators and the intermediate activated ionophores Heterogeneous interpenetrating polymer networks for the controlled release of drugs InventorsAssigneeApplicationNo. 726301 filed on 07/05/1991US Classes:424/78.17, Aftertreated polymer (e.g., grafting, blocking, etc.)424/78.08, SOLID SYNTHETIC ORGANIC POLYMER AS DESIGNATED ORGANIC ACTIVE INGREDIENT (DOAI)424/85.5, Gamma or immune424/179.1, Conjugated via claimed linking group, bond, chelating agent, or coupling agent (e.g., conjugated to proteinaceous toxin via claimed linking group, bond, coupling agent, etc.)424/181.1, Conjugated to nonproteinaceous bioaffecting compound (e.g., conjugated to cancer-treating drug, etc.)528/310, From imide- or lactam-containing compound, or from an amino-nitrogen containing carboxylic acid, or derivative of an amino-nitrogen-containing carboxylic acid530/390.1, Removing or inactivating virus or bacterium or component or product thereof (e.g., endotoxin, etc.)530/391.7, Conjugated to a cytotoxic agent, drug, or other biologically-active substance530/810CARRIER - BOUND OR IMMOBILIZED PEPTIDES OR PROTEINS AND THE PREPARATION THEREOF, E.G., BIOLOGICAL CELL OR CELL FRAGMENT AS CARRIER, ETC.ExaminersPrimary: Page, Thurman K.Assistant: Kulkosky, Peter F. Attorney, Agent or FirmInternational ClassesA61K 031/74A61K 039/00 C08G 069/08 AbstractCopolymers of poly(alkylene oxides) and amino acids or peptide sequences are disclosed, which amino acids or peptide sequences have pendant functional groups that are capable of being conjugated with pharmaceutically active compounds for drug delivery systems and cross-linked to form polymer matrices functional as hydrogel membranes. The copolymers can also be formed into conductive materials. Methods are also disclosed for preparing the polymers and forming the drug conjugates, hydrogel membranes and conductive materials.Other References
Field of SearchSOLID SYNTHETIC ORGANIC POLYMER AS DESIGNATED ORGANIC ACTIVE INGREDIENT (DOAI)Gamma or immune Aftertreated polymer (e.g., grafting, blocking, etc.) Removing or inactivating virus or bacterium or component or product thereof (e.g., endotoxin, etc.) Conjugated to a cytotoxic agent, drug, or other biologically-active substance From imide- or lactam-containing compound, or from an amino-nitrogen containing carboxylic acid, or derivative of an amino-nitrogen-containing carboxylic acid |
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