Certain pyridyl[(methylthio- or methyl sulfinyl)-2 benzimidazol-2-yl]N-methyl phosphonates useful for treating gastric-acid secretion related diseases
Patent 5215974 Issued on June 1, 1993. Estimated Expiration Date: February 8, 2011. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
514/80, Polycylo ring system having a ring nitrogen in the system514/89, Hetero ring is six-membered and includes only one ring nitrogen546/22, Phosphorus attached indirectly to the six-membered hetero ring by nonionic bonding546/137, Chalcogen bonded directly to ring carbon of the quinuclidine ring system546/269.7, 1,3-thiazoles (including hydrogenated)546/271.4, 1,3-oxazoles (including hydrogenated)546/273.1, Polycyclo ring system having the 1,3-diazole ring as one of the cyclos546/273.7Chalcogen bonded directly to a ring carbon of the 1,3-diazole ring
Novel compounds of the formula ##STR1## pharmaceutical compositions containing such compounds as active ingredient, and the use of the compounds in medicine for treating gastric acid related diseases such as gastritis, gastric ulcer, duodenal ulcer and reflux esophagitis.
Other References
Bundgaard, H., Design of Prodrugs, pp. 7-9, 21-24, Elsevier, Amsterdam, 1985
Juliano, R. L., Drug Delivery Systems, pp. 124-128, Oxford University Press, New York, 198