Method for the production of medical-grade lipid-coated microbubbles, paramagnetic labeling of such microbubbles and therapeutic uses of microbubbles
July 10, 2010. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesUltrasonic image enhancement Carrier liquid solutions for the production of gas microbubbles, preparation thereof, and use thereof as contrast medium for ultrasonic diagnostics Contact agents for ultrasonic imaging Surfactant mixtures, stable gas-in-liquid emulsions, and methods for the production of such emulsions from said mixtures Ultrasonic imaging agent and method of preparation Contrast medium for ultrasonic examinations and process for its preparation Lipisomes containing gas for ultrasound detection Liposome extrusion method A diagnostic agent containing a non-radioactive paramagnetic metal species in a macromolecular carrier Method for enhancing magnetic resonance imaging using an image altering agent containing an excess of chelating agent InventorAssigneeApplicationNo. 550620 filed on 07/10/1990US Classes:516/11, With particulate solid424/9.321, Liposome424/9.34, Polypeptide attached to or complexed with the agent (e.g., protein, antibody, etc.)424/405, Biocides; animal or insect repellents or attractants (e.g., disinfectants, pesticides, etc.)436/173, NUCLEAR MAGNETIC RESONANCE, ELECTRON SPIN RESONANCE OR OTHER SPIN EFFECTS OR MASS SPECTROMETRY514/938, Oil-water type516/18, The agent contains organic compound containing oxygen516/19, The compound contains -C(=O)OH group or salt thereof600/410, Magnetic resonance imaging or spectroscopy600/458Contrast enhancementExaminersPrimary: Lovering, Richard D.Assistant: Covert, John M. Attorney, Agent or FirmInternational ClassesB01J 013/00A61K 049/00 A61K 009/107 B01F 003/04 AbstractThis invention relates to a large scale method for the production of medical grade lipid-coated microbubbles, to the paramagnetic labeling of such microbubbles and to therapeutic applications for the microbubbles. More particularly, the invention relates to a method of the production of medical grade, concentrated suspensions of stable, paramagnetically derivatized or underivatized microbubbles useful for ultrasonic and magnetic resonance imaging and also relates to therapeutic interventions such as selective tumor destruction.Other References
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