ApplicationNo. 798138 filed on 11/26/1991
US Classes:530/345, Chemical aftertreatment, e.g., acylation, methylation, etc.530/402, Chemical modification or the reaction product thereof, e.g., covalent attachment or coupling, etc.530/406, Oxygen containing reactant568/335, Carbonyl bonded directly to benzene ring (i.e., acetophenones)568/337Oxy bonded directly to benzene ring
ExaminersPrimary: Cashion, Merrell C. Jr.
Assistant: Celsa, Bennett
Attorney, Agent or Firm
Foreign Patent References
International ClassesA61K 037/02
Foreign Application Priority Data1988-05-06 JP
AbstractA polyethylene glycol derivative of the formula ##STR1## wherein R represents a lower alkyl and n represents an optional positive integer which renders the average molecular weight of the polyethylene glycol moiety about 1,000 to 12,000, a peptide modified by said polyethylene glycol derivative and a method for production thereof. The polyethylene glycol derivative (I) is capable of modifying the guanidino groups in peptides. The peptides modified by the polyethylene glycol derivative (I) are extremely stable, are considerably delayed in biological clearance (i.e. the durability is extended) and exhibit their physiological activities effectively over the long period.
Field of SearchChemical aftertreatment, e.g., acylation, methylation, etc.
Chemical modification or the reaction product thereof, e.g., covalent attachment or coupling, etc.
Oxygen containing reactant
Nitrogen containing reactant
Benzene ring containing
Carbonyl bonded directly to benzene ring (i.e., acetophenones)
Oxy bonded directly to benzene ring
From phenol, phenol ether, or inorganic phenolate monomer
From ketone or ketene monomer