4-aminobutyric acid compounds, compositions and methods of use for treating disorders related to a dysfunction of GABAB receptors
Patent 5214063 Issued on May 25, 1993. Estimated Expiration Date: 
July 28, 2012. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
July 28, 2012. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 3316260 3573304 Certain 1H-imidazol-1-yl-1-lower-alkanoic acid derivatives having anti-thrombotic activity Imidazole derivatives and pharmaceutical compositions Patent #: 4636518 InventorsAssigneeApplicationNo. 920787 filed on 07/28/1992US Classes:514/394, Benzo fused at 4,5-positions of the diazole ring514/398, Chalcogen or nitrogen bonded directly to the imidazole ring by nonionic bonding514/400, At imidazole ring carbon514/419, C=X bonded directly or indirectly by an acyclic carbon or carbon chain to ring carbon of the five-membered hetero ring (e.g., tryptophan, etc.) (X is chalcogen)514/424, Chalcogen bonded directly to the five-membered hetero ring by nonionic bonding514/425, Plural chalcogens bonded directly to the five-membered hetero ring by nonionic bonding514/426, Nitrogen bonded directly to the five-membered hetero ring by nonionic bonding514/427, Two double bonds between ring members of the five-membered hetero ring (e.g., pyrrole, etc.)548/309.7, Nitrogen attached indirectly to the diazole ring by acyclic nonionic bonding548/338.1, Having -C(=X)-, wherein X is chalcogen, bonded directly to the nitrogen548/340.1, Chalcogen attached indirectly to the nitrogen by acyclic nonionic bonding548/495, Acyclic nitrogen bonded directly to the acyclic carbon or acyclic carbon chain548/543, Chalcogen bonded directly to a ring carbon of the five-membered hetero ring which is adjacent to the ring nitrogen (e.g., 2-pyrrolidones, etc.)548/544, And chalcogen bonded directly to a ring carbon of the five membered hetero ring which is not adjacent to the ring nitrogen (e.g., 2,4 pyrrolidinediones, etc.)548/550Nitrogen attached directly or indirectly to the five-membered hetero ring by acyclic nonionic bondingExaminersPrimary: Lee, Mary C.Assistant: Miltenberger, Lenora Attorney, Agent or FirmInternational ClassesC07D 207/337C07D 209/20 A61K 031/40 A61K 031/415 Foreign Application Priority Data1990-06-27 FRAbstractA compound of formula (I): ##STR1## in which R, R1 and R2 are as defined in the description. Medicinal product, which is useful in treating disorders related to a dysfunction of GABAB receptors.Other References
Field of SearchNitrogen attached indirectly to the diazole ring by acyclic nonionic bondingHaving -C(=X)-, wherein X is chalcogen, bonded directly to the nitrogen Chalcogen attached indirectly to the nitrogen by acyclic nonionic bonding Acyclic nitrogen bonded directly to the acyclic carbon or acyclic carbon chain Chalcogen bonded directly to a ring carbon of the five-membered hetero ring which is adjacent to the ring nitrogen (e.g., 2-pyrrolidones, etc.) And chalcogen bonded directly to a ring carbon of the five membered hetero ring which is not adjacent to the ring nitrogen (e.g., 2,4 pyrrolidinediones, etc.) Nitrogen attached directly or indirectly to the five-membered hetero ring by acyclic nonionic bonding Benzo fused at 4,5-positions of the diazole ring Chalcogen or nitrogen bonded directly to the imidazole ring by nonionic bonding At imidazole ring carbon C=X bonded directly or indirectly by an acyclic carbon or carbon chain to ring carbon of the five-membered hetero ring (e.g., tryptophan, etc.) (X is chalcogen) Chalcogen bonded directly to the five-membered hetero ring by nonionic bonding Plural chalcogens bonded directly to the five-membered hetero ring by nonionic bonding Nitrogen bonded directly to the five-membered hetero ring by nonionic bonding Two double bonds between ring members of the five-membered hetero ring (e.g., pyrrole, etc.) |
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