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Lactoferrin hydrolyzate for use as an antibacterial agent and as a tyrosinase inhibition agent

Patent 5214028 Issued on May 25, 1993. Estimated Expiration Date: Icon_subject December 27, 2010. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Method for separating bovine lactoferrin from cow's milk and purifying same
Patent #: 4668771
Issued on: 05/26/1987
Inventor: Kawakami ,   et al.

Process for producing bovine lactoferrin in high purity
Patent #: 4791193
Issued on: 12/13/1988
Inventor: Okonogi ,   et al.

Process for the preparation of protein hydrolysate and medicaments containing these hydrolysates
Patent #: 4918008
Issued on: 04/17/1990
Inventor: Gauri

Method for separating and purifying lactoferrin from milk by use of sulfuric ester Patent #: 4997914
Issued on: 03/05/1991
Inventor: Kawakami, et al.

Inventors

Assignee

Application

No. 634763 filed on 12/27/1990

US Classes:

514/6, Heavy metal containing (e.g., hemoglobin, etc.)424/94.1, ENZYME OR COENZYME CONTAINING424/94.66, Acid proteinases (3.4.23) (e.g., pepsin, renin, chymosin, etc.)426/56, With added enzyme, or added enzyme producing material or microorganism426/657, From animal435/68.1, Enzymatic production of a protein or polypeptide (e.g., enzymatic hydrolysis, etc.)514/8, Glycoprotein (carbohydrate containing)514/21, Produced by or extracted from animal tissue530/395, Glycoprotein, e.g., mucins proteoglycans, etc.530/397, Glycoprotein hormones530/407Hydrolysis of protein

Examiners

Primary: Schain, Howard E.

Attorney, Agent or Firm

Foreign Patent References

  • 62-249931 JP. 10/13/1987

International Classes

C07K 003/10
C07K 001/12

Foreign Application Priority Data

1990-01-23 JP

Abstract

Lactoferrin hydrolyzates, having a decomposition rate between 6%-20% as measured by formol titration, for use as an antibacterial agent and which have remarkly more potent activity than unhydrolyzed lactoferrin; and lactoferrin hydrolyzates, having a decomposition rate between 4-50% as measured by formol titration, for use as a tyrosinase inhibition agent, are obtainable by conventional methods for hydrolysis with acids or enzymes, and are stable to heating.

Other References

  • Chem. Abstracts, vol. 108, 1988, 226582q, Okonogi et al
  • Suzuki et al, Agric. Biol. Chem., vol. 53(6), pp. 1705-1706 (1989)
  • Spik et al., Biochimie, vol. 70 (1988), pp. 1459-146
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