Controlled release article with pulsatile release
May 25, 2010. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 3634584 Osmotic bursting drug delivery device Means for administering amphipathic medicament Sustained release pharmaceutical composition of solid medical material Process for producing a multi-layered slow release composite Process for preparing ethylcellulose microcapsules Osmotic system with instant drug availability Centering and safety device for rotors supported without contact Osmotic system with instant drug availability Pulsatile drug delivery system InventorsAssigneeApplicationNo. 505924 filed on 04/06/1990US Classes:424/473, With porous, perforated, apertured, or sieved layer (e.g., dialyzing layer, microporous layer, etc.)424/485, Natural gums, resin or latex424/488Polysaccharides (e.g., cellulose, etc.)ExaminersPrimary: Page, Thurman K.Assistant: Phelan, D. Gabrielle Attorney, Agent or FirmForeign Patent References
International ClassA61K 009/24Foreign Application Priority Data1989-09-22 DKAbstractAn article for controlled delivery of an active substance into an aqueous phase has a first layer containing an active substance, and a second layer of a crystalline polymer matrix and a non-ionic surface active agent, the second layer also containing the same or different active substance substantially homogeneously dispersed therein. The article enables release of a drug at a constant plateau level, followed by a pulse of drug after a predetermined time, thus making the composition of the invention especially suitable for use in, e.g., treatment of rheumatoid arthritis or related disorders with non-steroidal anti-inflammatory agents. | |
