U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Use of combinations gelling polysaccharides and finely divided drug carrier substrates in topical ophthalmic compositions

Patent 5212162 Issued on May 18, 1993. Estimated Expiration Date: Icon_subject March 25, 2012. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Ocular drug delivery device
Patent #: 4014335
Issued on: 03/29/1977
Inventor: Arnold

Mixed xanthan gum and locust beam gum therapeutic compositions
Patent #: 4136173
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Inventor: Pramoda ,   et al.

Xanthan gum therapeutic compositions
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Issued on: 01/23/1979
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Patent #: 4136178
Issued on: 01/23/1979
Inventor: Lin ,   et al.

Ethers of hydroxybenzothiazole-2-sulfonamide for the topical treatment of elevated intraocular pressure
Patent #: 4505923
Issued on: 03/19/1985
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Ophthalmological composition of the type which undergoes liquid-gel phase transition
Patent #: 4861760
Issued on: 08/29/1989
Inventor: Mazuel ,   et al.

Sustained release, comfort formulation for glaucoma therapy
Patent #: 4911920
Issued on: 03/27/1990
Inventor: Jani, et al.

Sustained release formulation containing an ion-exchange resin
Patent #: 4931279
Issued on: 06/05/1990
Inventor: Bawa, et al.

Viscoelastic fluid for use in surgery and other therapies and method of using same Patent #: 4983585
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Inventor: Pennell, et al.

Inventors

Assignee

Application

No. 857673 filed on 03/25/1992

US Classes:

514/54, Polysaccharide424/427, Ocular514/57, Cellulose or derivative514/912, OPHTHALMIC514/913, Glaucoma536/1.11, Carbohydrates or derivatives536/114, Gums or derivatives536/123.1Polysaccharides

Examiners

Primary: Wityshyn, Michael G.
Assistant: Leary, Louise N.

Attorney, Agent or Firm

International Classes

A61K 031/715
A61K 031/70

Abstract

Ophthalmic compositions comprising combinations of gelling polysaccharides and finely-divided drug carrier substrates which become relatively more viscous on contact with the eye are disclosed. These ophthalmic compositions are both comfortable and long-lasting Ophthalmic compositions further comprising a pharmaceutically active drug are also disclosed, as are methods of use.

Other References

  • Maren et al., Exp. Eye Res., 36: 457-480 (1983)
  • Maren et al., Exp. Eye Res., 50: 27-36 (1990)
  • Harris, P. (ed), Food Gels, New York: Elsevier Applied Science, 1990, Ch. 3 (pp. 79-119) and Ch. 6 (pp. 201-232)
  • McGraw-Hill Dictionary of Scientific and Technical Terms, Third Edition, New York: 1984 p. 164
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