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US Patent 5208219 - Method for inducing bone growth

US Patent Issued on May 4, 1993
Estimated Patent Expiration Date: Icon_subject February 14, 2011Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
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Abstract

Activin is administered systemically and locally to induce the growth of mature bone. Activin enhances the level of bone formation and the quality of the bone formed when administered locally with BMP or bone marrow. Administration of activin by subcutaneous route promotes systemic increase in the bone mass.

Other References

  • Vale et al., Nature (1986) 321:776-779
  • Sawchemko et al., Nature (1988) 334:615-617
  • Vale et al., Recent progress in Hormone Research (1988) 44:1-34
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  • Yu et al., Nature (1987) 330:765-767
  • Broxmeyer et al., Proc. Natl. Acad. Sci. (1988) 85:9052-9056
  • Murata et al., Proc. Natl. Acad. Sci. (1988) 85:2434-2438
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  • Meunier et al., Proc. Natl. Acad. Sci. (1988) 85:247-251
  • Broxmeyer et al., Exp Hematology, (N.Y.), 16(6), 474, 1988, (Biosis abstract available)
  • Seyedin et al., The J. of Biol. Chem., 261(13), 5693-5695, 198

Inventors

Assignee

Application

No. 655313 filed on 02/14/1991

US Classes:

514/12, 25 or more peptide repeating units in known peptide chain structure514/2, Peptide containing (e.g., protein, peptones, fibrinogen, etc.) DOAI514/8, Glycoprotein (carbohydrate containing)514/21, Produced by or extracted from animal tissue530/350, PROTEINS, I.E., MORE THAN 100 AMINO ACID RESIDUES530/397, Glycoprotein hormones530/399, Hormones, e.g., prolactin, thymosin, growth factors, etc.530/416, Ion exchange530/417Chromatography or by septum selective as to material, e.g., gel filtration, molecular sieve dialysis, etc.

Field of Search

514/2, Peptide containing (e.g., protein, peptones, fibrinogen, etc.) DOAI514/12, 25 or more peptide repeating units in known peptide chain structure514/8, Glycoprotein (carbohydrate containing)514/21, Produced by or extracted from animal tissue530/417, Chromatography or by septum selective as to material, e.g., gel filtration, molecular sieve dialysis, etc.530/416, Ion exchange530/399, Hormones, e.g., prolactin, thymosin, growth factors, etc.530/397, Glycoprotein hormones530/350PROTEINS, I.E., MORE THAN 100 AMINO ACID RESIDUES

Examiners

Primary: Moezie, F. T.

Attorney, Agent or Firm

US Patent References

5071834Purified activin B composition
Issued on: 12/10/1991
Inventor: Burton, et al.

International Classes

A61K 037/02
A61K 037/36

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