Indole derivatives, pharmaceutical compositions and methods of treating neurological and psychiatric disorders
Patent 5206382 Issued on April 27, 1993. Estimated Expiration Date: 
June 27, 2011. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
June 27, 2011. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.InventorsAssigneeApplicationNo. 722196 filed on 06/27/1991US Classes:548/494, Having -C(=X)-, wherein X is chalcogen, attached indirectly to ring carbon of the five-membered hetero ring by an acyclic carbon or acyclic carbon chain (e.g., indole-3-acetic acid, etc.)546/208, Ring nitrogen in the additional hetero ring548/465, Additional hetero ring, attached directly or indirectly to the bicyclo ring system by nonionic bonding548/466The additional hetero ring is bonded directly to a ring carbon of the bicyclo ring systemExaminersPrimary: Springer, David B.Attorney, Agent or FirmForeign Patent References
International ClassesC07D 401/12C07D 403/12 C07D 407/14 C07D 409/04 A61K 209/20 AbstractA compound having the formula: ##STR1## wherein R1 and R2 independently is selected from the group consisting of H, C3 -C12 straight or branched alkyl, aryl or lower alkyl-substituted aryl; or R1 and R2 may be joined to form a 4-to 6-membered saturated or unsaturated ring or a 4-to 6-membered saturated or unsaturated lower alkyl-substituted ring; R3 is H, C1 -C12 straight or branched alkyl, NO2, NH2, N3, CN, halogen, CO2 R, OR, or SR wherein R is H or lower alkyl; R4 is H, C1 -C12 straight or branched alkyl, NO2, NH2, N3, CN, halogen, CO2 R, OR, or SR wherein R is H or lower alkyl; A is nothing or a C1 -C5 alkylene to form a ring; Z is 0, NH, S or --CH=CH--; and n is an integer of 1-3; or a pharmaceutically acceptable salt thereof. The compounds are useful in compositions and methods for treating psychiatric and neurological disorders.Other References
Field of SearchHaving -C(=X)-, wherein X is chalcogen, attached indirectly to ring carbon of the five-membered hetero ring by an acyclic carbon or acyclic carbon chain (e.g., indole-3-acetic acid, etc.)Additional hetero ring, attached directly or indirectly to the bicyclo ring system by nonionic bonding The additional hetero ring is bonded directly to a ring carbon of the bicyclo ring system Ring nitrogen in the additional hetero ring C=X bonded directly to the piperidine ring (X is chalcogen) Additional hetero ring which is not part of the bicyclo ring system The bicyclo ring system consists of the five-membered hetero ring and a benzene ring (e.g., indole, etc.) |
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