Patent ReferencesInfusion device intended for implantation in a living body Implantable metered dose drug delivery system Liquid delivery system particularly useful as an implantable micropump for delivering insulin or other drugs Release rate adjustment of osmotic or diffusional delivery devices Electrochemically driven drug dispenser Implants for the promotion of healing of meniscal tissue Osmotically driven syringe Long-term delivery device including loading dose Implantable drug delivery system with piston actuation Implantable, self-regulating mechanochemical insulin pump InventorApplicationNo. 695107 filed on 05/03/1991US Classes:604/891.1, Implanted dynamic device or system424/424, Membrane or diffusion barrier424/425Diffusion barrier is matrixExaminersPrimary: Rosenbaum, C. FredAssistant: Polutta, Mark O. Attorney, Agent or FirmForeign Patent References
International ClassA61K 009/22AbstractThere is provided an implantable multiple-agent delivery system which includes a pod proportioned for subcutaneous implantation beneath the dermis of the skin, the pod including a porous surface having at least one internal chamber there within which is in fluid communication with the porous surface. The system further includes a dome proportioned for complemental, selectable detachable securement upon the pod. The dome includes a plurality of interior chambers, each in fluid communication with the internal chambers of the pod. Bio-acting agents, such as hormones, biologic response modifiers, free radical scavengers, and other therapeutic agents may be provided, within the chambers of the dome, prior to implantation. Such agents with the chambers of the dome will, through the use of time release microelectronics, enter at least one of the interior chambers of the pod for transmission, through the porous surfaces thereof, into a growth factor stimulated capillary matrix and then to the bloodstream of the user. The pod may be removed, refilled, and resecured to the dome upon exhaustion of its contents or upon medical requirement for changes in medication. The surface of the pod may be treated with one or vascular growth factors or related biologic molecules. | |