U.S. patents available from 1976 to present.
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Subcutaneous implantable multiple-agent delivery system

Patent 5201728 Issued on April 13, 1993. Estimated Expiration Date: Icon_subject May 3, 2011. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Infusion device intended for implantation in a living body
Patent #: 4511355
Issued on: 04/16/1985
Inventor: Franetzki ,   et al.

Implantable metered dose drug delivery system
Patent #: 4544371
Issued on: 10/01/1985
Inventor: Dormandy, Jr. ,   et al.

Liquid delivery system particularly useful as an implantable micropump for delivering insulin or other drugs
Patent #: 4596575
Issued on: 06/24/1986
Inventor: Rosenberg ,   et al.

Release rate adjustment of osmotic or diffusional delivery devices
Patent #: 4865845
Issued on: 09/12/1989
Inventor: Eckenhoff ,   et al.

Electrochemically driven drug dispenser
Patent #: 4886514
Issued on: 12/12/1989
Inventor: Maget

Implants for the promotion of healing of meniscal tissue
Patent #: 4952403
Issued on: 08/28/1990
Inventor: Vallee, et al.

Osmotically driven syringe
Patent #: 5030216
Issued on: 07/09/1991
Inventor: Theeuwes, et al.

Long-term delivery device including loading dose
Patent #: 5045082
Issued on: 09/03/1991
Inventor: Ayer, et al.

Implantable drug delivery system with piston actuation
Patent #: 5059175
Issued on: 10/22/1991
Inventor: Hanover, et al.

Implantable, self-regulating mechanochemical insulin pump
Patent #: 5062841
Issued on: 11/05/1991
Inventor: Siegel

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Inventor

Application

No. 695107 filed on 05/03/1991

US Classes:

604/891.1, Implanted dynamic device or system424/424, Membrane or diffusion barrier424/425Diffusion barrier is matrix

Examiners

Primary: Rosenbaum, C. Fred
Assistant: Polutta, Mark O.

Attorney, Agent or Firm

Foreign Patent References

  • 3317536 DE 11/20/1984
  • 2621248 FR 04/20/1989

International Class

A61K 009/22

Abstract

There is provided an implantable multiple-agent delivery system which includes a pod proportioned for subcutaneous implantation beneath the dermis of the skin, the pod including a porous surface having at least one internal chamber there within which is in fluid communication with the porous surface. The system further includes a dome proportioned for complemental, selectable detachable securement upon the pod. The dome includes a plurality of interior chambers, each in fluid communication with the internal chambers of the pod. Bio-acting agents, such as hormones, biologic response modifiers, free radical scavengers, and other therapeutic agents may be provided, within the chambers of the dome, prior to implantation. Such agents with the chambers of the dome will, through the use of time release microelectronics, enter at least one of the interior chambers of the pod for transmission, through the porous surfaces thereof, into a growth factor stimulated capillary matrix and then to the bloodstream of the user. The pod may be removed, refilled, and resecured to the dome upon exhaustion of its contents or upon medical requirement for changes in medication. The surface of the pod may be treated with one or vascular growth factors or related biologic molecules.

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