Digoxigenin derivatives and use thereof
Patent 5198537 Issued on March 30, 1993. Estimated Expiration Date: 
March 30, 2010. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
March 30, 2010. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 3855208 3925355 Radioimmunoassay method for the determination of cardiotonic glycosides Chemical process Digoxigenin immunogens, antibodies, labeled conjugates, and related derivatives Patent #: 4469797 InventorsAssigneeApplicationNo. 427249 filed on 10/25/1989US Classes:530/406, Oxygen containing reactant536/6.1, Oxygen containing five-membered hetero ring536/26.26, Triphosphates (in same chain)540/104, Nitrogen or sulfur attached directly or indirectly to the cyclopentanohydrophenanthrene ring system by nonionic bonding540/105Chalcogen bonded directly at the 14-position of the cyclopentanohydrophenanthrene ring system or double bond in the D ring (e.g., cardenolides, etc.)ExaminersPrimary: Bond, Robert T.Assistant: Ward, E. C. Attorney, Agent or FirmForeign Patent References
International ClassesC07H 021/04C07D 041/00 C07D 019/00 G01N 033/53 Foreign Application Priority Data1988-10-27 DEAbstractThe present invention provides digoxigenin derivatives of the formula: ##STR1## wherein n is a whole number of from 1 to 4 and Z is a carboxyl group or a functional derivative derived therefrom. The present invention also provides digoxigenin conjugates of the general formula: ##STR2## wherein the carrier is an immunogenic carrier material, a nucleic acid or a labelled immunocomponent of a labelled digoxigenin immunoconjugate for use in an immunoassay, m is a number from 1 to the number of coupling positions available on the carrier and Y is the group formed by the reaction of the carboxyl function Z of the digoxigenin derivative of general formula (I) with the reacting position of the carrier material. Also described are uses of these conjugates as nucleic acid probes, immunogens, and in immunoassay.Other References
Field of SearchNitrogen or sulfur attached directly or indirectly to the cyclopentanohydrophenanthrene ring system by nonionic bondingChalcogen bonded directly at the 14-position of the cyclopentanohydrophenanthrene ring system or double bond in the D ring (e.g., cardenolides, etc.) Oxygen containing five-membered hetero ring Oxygen containing reactant Chemical aftertreatment, e.g., acylation, methylation, etc. Nitrogen containing reactant Binds hormone or other secreted growth regulatory factor, differentiation factor, intercellular mediator, or neurotransmitter (e.g., insulin, human chorionic gonadotropin, intragonadal regulatory protein, Mullerian inhibiting substance, inhibin, epidermal growth factor, nerve growth factor, dopamine, norepinephrine, etc.) |
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