Formulation for delivery of drugs by metered dose inhalers with reduced or no chlorofluorocarbon content

Patent 5190029 Issued on March 2, 1993. Estimated Expiration Date:

June 26, 2011. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Abstract Claims Description Full Text

Patent References

3137416

3592364

3825159

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Inventors

Assignee

Virginia Commonwealth University

Application

No. 721698 filed on 06/26/1991

US Classes:

128/200.14, LIQUID MEDICAMENT ATOMIZER OR SPRAYER128/200.23, Pre-pressurized container holding medicament128/203.15, Particulate treating agent carried by breathed gas128/203.23, Pocket-type draw tube having discharge aperture for air/treating agent mixture at end thereof222/635, Pressurized aerosol container424/45, Organic pressurized fluid424/46Powder or dust containing

Examiners

Primary: Lovering, Richard D.

Attorney, Agent or Firm

Whitham & Marhoefer

Foreign Patent References

0372777 EP. 11/13/1989

International Classes

A61K 009/12
A61M 011/00
C09K 003/30

Abstract

Aerosol formulations for use in metered dose inhalers are disclosed which include 1,1,1,2-tetrafluoroethane alone and in combination with other compounds as well as various hydrocarbon blends. The density, vapor pressure, flame extension characteristics, dispersability of medicant, dissolvability of surfactant, respirable fraction, and compatibility elastomer seals for the aerosol formulations have been examined. The aerosol formulations are attractive alternatives to chlorofluorocarbon based aerosols since they do not deplete the ozone layer.

Other References

Nelson et al.: "Alternative Formulation to Reduce CFC Use in U.S. Exempted and Excluded Aerosol Products", EPA-600/2-89-061, Nov. 1989
Dalby et al.: "CFC Propellant Substitution: P-134a as a Potential Replacement for P-12 in MDI's", Pharm. Tech., Mar., 1990
Dalby & Byron, "Comparison of Output Particle Size Distributions from Pressurized Aerosols Formulated as Solutions and Suspensions", Pharm. Res. 5, 36-39 (1988)
British Pharmacopoeia, p. 875, Appendix XVIIC, A204-A207 (1988)
Nelson et al., Alternative Formulations to Reduce CFC use in U.S. EPA Contract No. 68-02-428