U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Treatment of cocaine addiction

Patent 5189064 Issued on February 23, 1993. Estimated Expiration Date: Icon_subject May 14, 2010. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Novel derivatives of beta-endorphin, intermediates therefor and compositions and methods employing said derivatives
Patent #: 4312857
Issued on: 01/26/1982
Inventor: Coy ,   et al.

Nutritional composition for management of renal failure
Patent #: 4357343
Issued on: 11/02/1982
Inventor: Madsen ,   et al.

Class of analgesics and/or anti-inflammatory agents consisting of inhibitors of breakdown of endogenous enkephalin and/or endorphin, and combinations of said analgesics with antipyretic, anti-inflammatory (aspirin-type) drugs Patent #: 4439452
Issued on: 03/27/1984
Inventor: Ehrenpreis ,   et al.

Inventors

Assignee

Application

No. 523300 filed on 05/14/1990

US Classes:

514/561, Nitrogen other than as nitro or nitroso nonionically bonded514/810, ADDICTION514/811, Alcohol514/812Narcotic

Examiners

Primary: Friedman, S. J.

Attorney, Agent or Firm

Foreign Patent References

  • 8203551 WO 10/13/1982

International Class

A61K 031/195

Abstract

Cocaine addiction is treated by administration of an endorphinase or enkephalinase inhibitor, and optionally, a dopamine precursor, or a serotonin precursor, a GABA precursor, or an endorphin or enkephalin releaser. These components promote restoration of normal neurotransmitter function and are non-addictive. Use of the dopamine precursors L-phenylalanine or L-tyrosine, the enkephalinase inhibitor D-phenylalanine and/or the serotonin precursor L-tryptophan is especially preferred.

Other References

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  • Schwartz, et al.; Neuropharmacology 17:665-685 (1978); Modulation of Receptor Mechanisms in the CNS:Hyper and Hyposensitivity to Catecholamines
  • Letter to the Editor; J. Pharm. Pharmac., 24:905-06 (1972); Dopamine turnover in the Corpus Striatum and the Limbic System After Treatment with Neuroleptic and Anti-acetylcholine Drugs
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