Formulations for delivery of drugs by metered dose inhalers with reduced or no chlorofluorocarbon content
February 14, 2011. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 3644353 Piperidine derivatives Piperidine derivatives 1-Piperidine-alkanol derivatives, pharmaceutical compositions thereof, and method of use thereof 1-Piperidine-alkylene ketones, pharmaceutical compositions thereof and method of use thereof Process for the manufacture of 1,1,1,2-tetrafluoroethane Acyl and ester derivatives of 1,3-diazabicyclo[3,3,0]octane Aerosol waterproof sunscreen compositions Dry aerosol foam Volatile foaming agent composition InventorsAssigneeApplicationNo. 655668 filed on 02/14/1991US Classes:424/45, Organic pressurized fluid514/653, Hydroxy, bonded directly to carbon, attached directly or indirectly to the acyclic carbon or chain by acyclic nonionic bonding (e.g., beta hydroxy phenethylamines, etc.)514/784, Carboxylic acid or salt thereof514/970CONTAINING DESIGNATED INGREDIENT TO STABILIZE AN ACTIVE INGREDIENTExaminersPrimary: Page, Thurman K.Assistant: Levy, Neil S. Attorney, Agent or FirmForeign Patent References
International ClassesA61K 009/12A61K 031/135 C07C 019/08 AbstractAerosol formulations for use in metered dose inhalers are disclosed which include 1,1,1,2-tetrafluoroethane alone and in combination with other compounds as well as various hydrocarbon blends. The density, vapor pressure, flame extension characteristics, dispersability of medicant, dissolvability of surfactant, respirable fraction, and compatibility elastomer seals for the aerosol formulations have been examined. The aerosol formulations are attractive alternatives to chlorofluorocarbon based aerosols since they do not deplete the ozone layer.Other References
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