U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Aqueous folinate solution stable at refrigerator temperature, as well as process for its preparation

Patent 5177076 Issued on January 5, 1993. Estimated Expiration Date: Icon_subject January 5, 2010. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

2695860

Steroid formulation containing dipotassium EDTA
Patent #: 4344940
Issued on: 08/17/1982
Inventor: Chow ,   et al.

Stabilized estradiol cream composition Patent #: 4436738
Issued on: 03/13/1984
Inventor: Bequette ,   et al.

Inventors

Assignee

Application

No. 440129 filed on 11/21/1989

US Classes:

514/249, 1,4-diazine as one of the cyclos514/970CONTAINING DESIGNATED INGREDIENT TO STABILIZE AN ACTIVE INGREDIENT

Examiners

Primary: Waddell, Frederick E.
Assistant: Criares, T. J.

Attorney, Agent or Firm

Foreign Patent References

  • 2381047 FR. 09/13/1978

International Class

A61K 031/495

Foreign Application Priority Data

1989-06-06 NL

Abstract

An aqueous folinate solution stable at refrigerator temperature is provided which contains folinate ions, complexed calcium ions, and if desired free calcium ions in a total amount of more than 12 mg/ml, as well as anions of a complexing agent for calcium. This solution is prepared by incorporating the complexing agent therein.

Other References

  • Bundesverband der Pharmazeutischen Industrie "Roto Liste", 1989, Editio Cantor, Aulendorf/Wurtt., De No. 12-022 Leucovorin
  • Journal of Phamaceutical Sciences, vol. 69, No. 2, Feb. 1980, blz. 234, American Pharmaceutical Assocation; K. R. Scott et al.: "Drug interactions I: folic acid and calcium gluconate
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