Reagents for detecting and assaying nucleic acid sequences
Patent 5175270 Issued on December 29, 1992. Estimated Expiration Date: 
December 29, 2009. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
December 29, 2009. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesJunction-fragment DNA probes and probe clusters Reagent polynucleotide complex with multiple target binding regions, and kit and methods Method of detecting nucleic acid sequences Method and kit involving displacement and rehybridization of labeled polynucleotide Nucleic acid hybridization assays Dendritic molecules and method of production Patent #: 5041516 InventorsAssigneeApplicationNo. 906222 filed on 09/10/1986US Classes:536/24.32, Probes for detection of microbial nucleotide sequences435/6, Involving nucleic acid436/501, BIOSPECIFIC LIGAND BINDING ASSAY436/811TEST FOR NAMED DISEASE, BODY CONDITION OR ORGAN FUNCTIONExaminersPrimary: Yarbrough, Amelia B.Assistant: Marschel, Ardin H. Attorney, Agent or FirmForeign Patent References
International ClassesC07H 021/00C12Q 001/68 AbstractA novel class of reagents for assaying nucleic acid sequences comprise successive layers of polynucleotides of a specific structure, including a double-stranded waist and single-stranded, free arms at the molecule ends, formed by hybridization of the arms to adjacent molecule arms. The reagent is used to assay for specific nucleic acid sequences. The outer layer of polynucleotides are specific for the sequence to be assayed through their non-annealed, free, single-stranded arms. The reagents are useful in the assay of a wide variety of nucleic acid sequences including those associated with pathogens such as pathogenic bacteria and virus.Other References
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