Method for preparing samples for mass analysis by desorption from a frozen solution
Apparatus and method for laser desorption of molecules for quantitation Patent #: 4988879
ApplicationNo. 826924 filed on 01/24/1992
US Classes:250/288, With sample supply means73/863.11, With heating or cooling73/864.81, Analyzer supplier422/81Automated system with sample fluid pressure transport means
ExaminersPrimary: Berman, Jack I.
Attorney, Agent or Firm
International ClassH01J 049/04
AbstractA method and apparatus for continuously introducing samples for mass spectrometry analysis which comprises providing sample molecules in an aqueous solution containing one or more organic solvents, preferably ethylene glycol, introducing said aqueous solution into the vacuum chamber of an ion source to enable said solution to solidify into a thread of solid matrix, and exposing the solid matrix to a source of energy to desorb sample molecules to be analyzed. The desorbed molecules are then photoionized and focused into a mass spectral analysis zone. The technique is suitable for interfacing liquid chromatographic separation techniques.