Emulsions
Patent 5171737 Issued on December 15, 1992. Estimated Expiration Date: 
December 15, 2009. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
December 15, 2009. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 3004892 Liposome drug delivery systems Stabilization of oil and water emulsions using polyglycerol esters of fatty acids Oil-in-water emulsion for parenteral administration Process for producing W/O/W type multiple emulsion for medicines Patent #: 4988456 InventorsApplicationNo. 318774 filed on 03/03/1989US Classes:514/3, Insulin or derivative514/938, Oil-water type514/944, GEL514/975CHARACTERIZED BY THE DESIGNATED SURFACTANT USEDExaminersPrimary: Springer, David B.Attorney, Agent or FirmInternational ClassesA61K 009/107A61K 009/10 A61K 009/113 AbstractA novel oil and water emulsion useful for delivery of a bioactive agent is disclosed. The emulsion comprises a first HLB requirement amount of surfactant dioleoyl phosphatidylethanolamine. In particular embodiments the emulsion includes a secondary surfactant other than dioleoyl phosphatidylethanolamine except in the limiting case wherein the HLB requirement is the HLB value of dioleoyl phosphatidylethanolamine in which case the HLB requirement amount of a secondary surfactant is 0. By appropriate selection of dioleoyl phosphatidylethanolamine to secondary surfactant ratios, it is possible to prepare emulsions for pharmaceutical delivery of a bioactive agent using an oil phase having a required HLB value up to about 17.4. Above a required HLB value of about 17.4. dioleoyl phosphatidylethanolamine may be used to reduce the amount of secondary surfactant required to form an emulsion.Other References
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