U.S. patents available from 1976 to present.
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Immobilized polyethylene oxide star molecules for bioapplications

Patent 5171264 Issued on December 15, 1992. Estimated Expiration Date: Icon_subject February 28, 2010. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

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Surface coated article, process and means for the preparation thereof and use thereof
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Hybrid acrylic star polymers
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Inventor

Application

No. 486153 filed on 02/28/1990

US Classes:

623/3.1, CORPOREAL ARTIFICIAL HEART, HEART ASSIST (E.G., IMPLANTABLE BLOOD PUMP, ETC.), CONTROL REGULATOR, OR POWER SUPPLY THEREFOR, OR METHOD OF OPERATION THEREFOR427/2.24, Implantable permanent prosthesis (i.e., artificial body member) (e.g., pacemaker, lens, cornea, glaucoma shunt, heart valve, muscle, spinal disc, breast, internal organ)427/2.25, Liquid conveying (e.g., vascular, arterial, bile duct, urethra)427/2.28, Device for creating or holding open an unnatural opening in a membrane or organ (e.g., syringe, scalpel, drainage tube)427/2.3, Fluid barrier or fluid transporting product, other than merely absorbing (e.g., surgical glove, condom, lined diaper, membrane filter, IV tubing, cannula, dialysis membrane, urinary catheter)427/337, Chemical agent applied to treat coating427/352, Liquid extraction of coating constituent or cleaning coating427/533, Ionized gas utilized (e.g., electrically powered source, corona discharge, plasma, glow discharge, etc.)435/975, KIT436/512, INVOLVING ANTIBODY FRAGMENTS436/518, INVOLVING AN INSOLUBLE CARRIER FOR IMMOBILIZING IMMUNOCHEMICALS436/547, INVOLVING PRODUCTION OR TREATMENT OF ANTIBODY436/828, PROTEIN A606/194Inserted in vascular system

Examiners

Primary: Beck, Shrive
Assistant: Dudash, Diana

Attorney, Agent or Firm

Foreign Patent References

  • 0068509 EP. 01/13/1983
  • 0263184 EP. 04/13/1988
  • 0332261 EP. 09/13/1989

International Class

A61M 001/10

Abstract

This invention pertains to a method for immobilizing polyethylene oxide (PEO) star molecules in the form of hydrogels. the PEO star molecules are biocompatible and demonstrate non-thrombogenic properties. As such, the PEO star molecules have numerous uses for biomedical applications. The hydrogels contain a high percentage of terminal hydroxyl groups for attachment of affinity ligands and can be used for separating and purifying therapeutic proteins.

Other References

  • Rempp, R. & P. Lutz, Abstracts of the Papers of the American Chemical Society 196: 27-Poly (1988)
  • Rempp, P. et al., Advances in Polymer Science 86:145-173 (1988)
  • Taromi, F. A. and P. Rempp, Makromol. Chem. 190:1791-1798 (1989)
  • Gnanou, Y. et al., Makromol. Chem. 189:2885-2892 (1988)
  • Lutz, P. and P. Rempp, Makromol. Chem. 189:1051-1060 (1988)
  • Remp, P. et al., American Chemical Society, Polymer Division Symposium, Boston, MA Apr. 1990
  • Merrill, E. W. et al., The 16th Annual Meeting of the Society for Biomaterials, Charleston, SC, May 20-23, 1990
  • Tay, S. W. et al., Biomaterials 10:11-15 (1989
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