Hyaluronics acid fractions, methods for the preparation thereof, and pharmaceutical compositions containing same
Patent 5166331 Issued on November 24, 1992. Estimated Expiration Date: 
December 19, 2009. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
December 19, 2009. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 3870791 Ultrapure hyaluronic acid and the use thereof Polyvinyl alcohol ophthalmic gel Patent #: 4255415 InventorsAssigneeApplicationNo. 452681 filed on 12/19/1989US Classes:536/55.1, Polysaccharides424/78.05, Anti-inflammatory or anti-irritant (e.g., anti-arthritic, etc.)514/54, Polysaccharide514/420, Indomethacine per se or ester thereof514/576, Benzene ring containing514/777, Carbohydrate or lignin, or derivative514/912OPHTHALMICExaminersPrimary: Nutter, Nathan M.Attorney, Agent or FirmInternational ClassesC07H 005/04C07H 005/06 A01N 043/04 A61K 037/715 Foreign Application Priority Data1983-10-10 ITAbstractTwo pharmaceutically useful fractions of hyaluronic acid are obtained comprising a first fraction with a molecular weight between 50,000 and 100,000 which is useful for wound healing, and a second fraction having a molecular weight between 500,000 and 730,000 which is useful for intraocular and intraarticular injections.In addition, pharmaceutical preparations for topical administration are provided containing a pharmacologically active substance together with hyaluronic acid or a molecular weight fraction thereof. The hyaluronic acid may be in the form of the free acid or may be a salt with an alkali or alkaline earth metal, magnesium, aluminum or ammonium, or in the form of a salt with one or more pharmacologically active substances.Other References
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