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Method for enhancing the systemic delivery of dextromethorphan for the treatment of neurological disorders

Patent 5166207 Issued on November 24, 1992. Estimated Expiration Date: Icon_subject June 17, 2011. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Inventor

Assignee

Application

No. 717424 filed on 06/17/1991

US Classes:

514/270Barbituric acid or derivative (including thioanalogs)

Examiners

Primary: Friedman, S. J.

Attorney, Agent or Firm

International Class

A61U 031/515

Abstract

A method for enhancing the systemic delivery of dextromethorphan for the treatment of a neurological disorder resulting in injury to nervous tissue, which comprises administering to a patient suffering from the disorder an amount of a cytochrome P450IID6 enzyme inhibitor, sufficient to block dextromethorphan metabolism, and an amount of dextromethorphan sufficient to treat the neurological disorder. Quinidine is particularly suitable for use in the method of the invention.

Other References

  • Chem. Abst. 111-89742z, (1989
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