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Method for the treatment of panic disorder

Patent 5166202 Issued on November 24, 1992. Estimated Expiration Date: Icon_subject December 13, 2011. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Nasal administration of benzodiazepine hypnotics Patent #: 4950664
Issued on: 08/21/1990
Inventor: Goldberg

Inventor

Assignee

Application

No. 809205 filed on 12/13/1991

US Classes:

514/220, Tricyclo ring system having the seven-membered hetero ring as one of the cyclos514/219Polycyclo ring system having the seven-membered hetero ring as one of the cyclos

Examiners

Primary: Waddell, Frederick E.
Assistant: Criares, T. J.

Attorney, Agent or Firm

International Class

A01N 043/62

Abstract

Midazolam and its pharmaceutically acceptable salts are useful in the treatment of panic disorder, panic attacks and the prevention of panic attacks.

Other References

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  • Noyes, R. et al., "Problems with tricyclic antidepressant use in patients with panic disorder or agoraphobia: results of a naturalistic follow-up study," J. Clin. Psychiatry, 50163-169 (1989)
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  • Noyes, R. et al., "Follow-up study of patients with panic disorder and agoraphobia with panic attacks treated with tricyclic antidepressants," J. Affective Disord, 16:249-257 (1989)
  • Mavissakalian, M. et al., "Imipramine in the treatment of agoraphobia: dose-response relationships," Am J. Psychiatry, 142:1032-1036 (1985)
  • Rickels, K. et al., "Chronic therapeutic use of benzodiazepines: I. Effects of abrupt discontinuation," Arch Gen Psychiatry (in press)
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  • Roy-Byrne, P. P. et al., "Benzodiazepine withdrawal: overview and implications for the treatment of anxiety." Am J. Med., 84:1041-1052 (1988)
  • Reves, J. G. et al., "Midazolam" pharmacology and uses, Anesthesiology, 62:310-324 (1985)
  • Dundee, J. W. et al., "Midazolam" a review of its pharmacological properties and therapeutic use, Drugs, 28:519-541 (1984)
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  • O'Boyle, C. A. et al., "Comparison of midazolam by mouth and diazepam IV in outpatient oral surgery," Br J. Anaesth, 59:746-754 (1987)
  • Hargreaves, J., "Benzodiazepine premedication in minor day-case surgery: comparison of oral midazolam and temazepam with placebo," Br J. Anaesth, 61:611-616 (1988)
  • Clausen, T. G., et al., "Pharmacokinetics of midazolam and alpha-hydroxy-midazolam following rectal and intravenous administration," Br J. Clin. Pharmacol, 25:457-463 (1988)
  • Wilton, N. C. T. et al., "Preanesthetic sedation of preschool children using intranasal midazolam," Anesthesiology, 69:972-975 (1988)
  • Noyes, R. et al., "Alprazolam in panic disorder and agoraphobia: Results from a multicenter trial. II. Patient acceptance, side effects, and safety," Arch Gen Psychiatry, 45:423-428 (1988)
  • Greenblatt, D. J. et al., "Pharmacokinetic and electroencephalographic study of intravenous diazepam, midazolam, and placebo," Clin. Pharmacol Ther, 45:356-365 (1989)
  • Sostmann, H. J. et al., "Dose equivalence of midazolam and triazolam," Eur J. Clin Pharmacol, 36:181-187 (1989)
  • Forster A., "Respiratory depressant effects of different doses of midazolam and lack of reversal with naloxone-a double-blind randomized study", Anesth Analg, 62:920-924 (1983)
  • Curtis, L. D. et al., "Arterial oxygen desaturation following intravenous injection of midazolam," J Amer Assoc of Nurse Anesth, 57:244-249 (1989)
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  • Rickels, K. et al., "Long-term treatment of anxiety and risk of withdrawal. Prospective comparison of clorazepate and buspirone," Arch Gen Psychiatry, 45:444-450 (1988)
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  • Koopmans, R. et al., "Pharmacokinetic-pharmacodynamic modeling of midazolam effects on the human central nervous system," Clin Pharmacol Ther, 44:14-22 (1988)
  • Schweizer, E. et al., "Lorazepam vs. alprazolam in the treatment of panic disorder," Pharmacopsychiatry, 23:90-93 (1990)
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