Methotrexate compositions and methods of treatment using same
Patent 5166149 Issued on November 24, 1992. Estimated Expiration Date: 
June 10, 2011. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
June 10, 2011. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesProcess for preparing dialkyl (p-aminobenzoyl) glutamates Additive combination for hydraulic cement compositions Patent #: 4375987 InventorAssigneeApplicationNo. 713558 filed on 06/10/1991US Classes:514/186Bicyclo ring systemExaminersPrimary: Waddell, Frederick E.Assistant: Fay, Zohreh Attorney, Agent or FirmInternational ClassA61K 031/555AbstractCompositions containing metal salts of methotrexate and methotrexate derivatives or analogs are disclosed. Such compositions comprise a metal salt, preferably a zinc salt, of methotrexate or a methotrexate derivative or analog and a carrier suitable for delivering the metal salt in the desired pharmacological form. Methods of treatment are also disclosed in which such compositions are topically applied or orally or parenterally administered to a patient. The metal salt is present in the treating composition in an amount sufficient to produce the desired therapeutic effect upon application or administration.Other References
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