U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Transdermal therapeutic formulation containing a limonene

Patent 5164416 Issued on November 17, 1992. Estimated Expiration Date: Icon_subject May 8, 2011. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

3023144

3797494

Topical application of prostaglandin hypotensive agents
Patent #: 4254145
Issued on: 03/03/1981
Inventor: Birnbaum

Disinfectant/cleanser compositions exhibiting reduced eye irritancy potential
Patent #: 4336151
Issued on: 06/22/1982
Inventor: Like ,   et al.

Pesticides containing D-limonene
Patent #: 4379168
Issued on: 04/05/1983
Inventor: Dotolo

Pharmaceutical preparation for endermic application
Patent #: 4474798
Issued on: 10/02/1984
Inventor: Inagi ,   et al.

Base composition for external preparations, pharmaceutical composition for external use and method of promoting percutaneous drug absorption
Patent #: 4593048
Issued on: 06/03/1986
Inventor: Sato ,   et al.

Base composition for medicament and pharmaceutical composition for external medication
Patent #: 4594243
Issued on: 06/10/1986
Inventor: Satoh ,   et al.

Method for percutaneously administering physiologically active agents
Patent #: 4710497
Issued on: 12/01/1987
Inventor: Heller ,   et al.

2,3-dihydro-2-(4,5-dihydroimidazol-2-yl)-indoles for reducing intraocular pressure Patent #: 4912125
Issued on: 03/27/1990
Inventor: Huebner, et al.

Inventors

Assignee

Application

No. 700046 filed on 05/08/1991

US Classes:

514/763, Carbocyclic514/165, Aspirin per se (i.e., 2-(acetyloxy)benozic acid)514/270, Barbituric acid or derivative (including thioanalogs)514/404, Divalent chalcogen or acyclic nitrogen double bonded directly to ring carbon of the diazole ring, or tautomeric equivalent514/420, Indomethacine per se or ester thereof514/570, Carboxy or salt thereof only attached indirectly to the benzene ring514/663, Acyclic514/667, C-O-group containing514/686, Two benzene rings bonded directly to the same C=O514/817, ANESTHETIC, TOPICAL514/947Topical application

Examiners

Primary: Raymond, Richard L.
Assistant: Hollinden, Gary E.

Attorney, Agent or Firm

International Classes

A61K 031/015
A61K 031/60
A61K 031/515

Foreign Application Priority Data

1989-02-03 JP

Abstract

A transdermal therapeutic formulation comprising d-limonene and at least one pharmaceutically active substance wherein the content of the d-limonene is in the range from 0.1 to 2 weight percent, based on the total amount of the formulation. The transdermal therapeutic formulation has an excellent percutaneous absorption, is safe and is capable of delivering desired pharmaceutically active substances to a desired location of treatment or to the entire body of a patient through the circulatory system and is thus effective for curing various diseases.

Other References

  • Merck Index, p. 788, 10th Edition, Entry No. 5321 "Limonene" (1983
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