Heterocyclic peptide renin inhibitors
Patent 5164388 Issued on November 17, 1992. Estimated Expiration Date: 
April 18, 2011. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
April 18, 2011. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 2501455 3121717 3796703 Novel derivatives of N-(3,4,5-trimethoxy cinnamoyl)piperazine and the process for preparing them Hypotensive peptides and their use Aniline derivatives and cardiotonic composition Renin inhibiting compounds Renin inhibiting compounds N-(acyldipeptidyl)-aminoglycols Modified phenylalanine peptidylaminodiols InventorsApplicationNo. 678266 filed on 04/18/1991US Classes:514/235.8, Plural ring nitrogens in the additional hetero ring (e.g., imidazole, pyrazine, etc.)514/18, 3 or 4 peptide repeating units in known peptide chain514/217.05, Plural ring hetero atoms in the additional hetero ring514/230.8, Chalcogen bonded directly to ring carbon of 1,4-oxazine ring514/231.5, Additional hetero ring attached directly or indirectly to the morpholine ring by nonionic bonding514/254.02, The additional five-membered hetero ring also has chalcogen as a ring member514/315, Piperidines514/326, The additional ring is a hetero ring514/345, Chalcogen bonded directly to ring carbon of the six-membered hetero ring514/397, Additional hetero ring540/492, Plural nitrogens in the hetero ring544/121, Piperazine ring544/132, Five-membered hetero ring having two or more ring hetero atoms of which at least one is nitrogen544/295, Plural diazine rings544/357, Plural diazine rings544/360, Six-membered ring consisting of one nitrogen and five carbons (e.g., pyridine, etc.)544/369, 1,3-oxazole ring or 1,3-thiazole ring (including hydrogenated)544/370, 1,3-diazole ring (including hydrogenated)544/375, Polycyclo ring system having the additional hetero ring as one of the cyclos544/384, Chalcogen bonded directly to piperazine ring carbon544/385, Plural chalcogens bonded directly to piperazine ring carbons544/392, Phenyl or naphthyl bonded directly to ring nitrogen of the piperazine ring544/398Chalcogen attached indirectly to the piperazine ring by nonionic bondingExaminersPrimary: Daus, Donald G.Attorney, Agent or FirmForeign Patent References
International ClassA61K 031/495AbstractA renin inhibiting compound of the formula ##STR1## wherein X is N, O or CH; R1 is absent or a functional group; A and L are independently selected from absent, C=O, SO2 and CH2 ; D is C=O, SO2 or CH2 ; Y is N or CH; R2 is hydrogen, loweralkyl or substituted alkyl; Z is a functional group; R3 is loweralkyl or substituted alkyl; n is 0 or 1; and T is a mimic of the Leu-Val cleavage site of angiotensinogen; or a pharmaceutically acceptable salt, ester or prodrug thereof.Other References
Field of Search3 or 4 peptide repeating units in known peptide chainPlural ring nitrogens in the additional hetero ring (e.g., imidazole, pyrazine, etc.) Containing at least one abnormal peptide link, e.g., gamma peptide bonded, etc. Plural diazine rings Plural diazine rings Six-membered ring consisting of one nitrogen and five carbons (e.g., pyridine, etc.) 1,3-oxazole ring or 1,3-thiazole ring (including hydrogenated) 1,3-diazole ring (including hydrogenated) Polycyclo ring system having the additional hetero ring as one of the cyclos |
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