Heterocyclic ketones
Patent 5164371 Issued on November 17, 1992. Estimated Expiration Date: 
November 17, 2009. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
November 17, 2009. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesProline derivatives Peptide elastase inhibitors and methods Proline derivatives Selected difluoro derivatives Peptide derivatives Patent #: 4910190 InventorsAssigneeApplicationNo. 193317 filed on 05/11/1988US Classes:514/18, 3 or 4 peptide repeating units in known peptide chain514/19, 2 peptide repeating units in known peptide chain530/331, Tripeptides, e.g., tripeptide thyroliberin (TRH), melanostatin (MIF), etc.544/297, Nitrogen attached directly at 2-position by nonionic bonding and sulfur bonded directly to the nitrogen544/322, Nitrogen attached directly to diazine ring by nonionic bonding544/333, Additional hetero ring which is unsaturated546/293, Sulfur bonded directly to acyclic nitrogen546/306, Plural acyclic nitrogens bonded directly to the same carbon or single bonded directly to each other546/332, Plural acyclic nitrogens bonded directly to the same carbon or single bonded directly to each other548/110, Boron or silicon containing548/159, Additional polycyclo heterocyclic ring system containing548/179, Chalcogen attached indirectly to the bicyclo ring system by nonionic bonding548/188, The -C(=X)- group is bonded directly to the thiazole ring548/205, Nitrogen attached indirectly to the thiazole ring by nonionic bonding548/217, Polycyclo ring system having the oxazole ring as one of the cyclos548/228, Chalcogen bonded directly at 5-position of the oxazole ring548/233, Nitrogen bonded directly to ring carbon of the oxazole ring548/235, Plural double bonds between the ring members of the oxazole ring548/237One double bond between the ring members of the oxazole ringExaminersPrimary: Bond, Robert T.Assistant: Ward, Edward C. Attorney, Agent or FirmInternational ClassesC07D 237/08C07D 239/06 C07K 005/08 A61K 037/02 Foreign Application Priority Data1987-05-11 GBAbstractThe invention provides a series of novel heterocyclic ketones of formula I ##STR1## and pharmaceutically acceptable base-addition salts thereof, in which the values of R4, L, A, X and Q have the meanings defined in the following specification. The compounds of formula I are inhibitors of human leukocytic elastase. The invention also provides pharmaceutical compositions containing a compound of formula I, or a pharmaceutically acceptable base-addition salt thereof, and processes and intermediates for the manufacture of compounds of formula I.Other References
Field of Search3 or 4 peptide repeating units in known peptide chain2 peptide repeating units in known peptide chain Tripeptides, e.g., tripeptide thyroliberin (TRH), melanostatin (MIF), etc. Chalcogen or nitrogen attached directly to the other cyclo of the bicyclo ring system by nonionic bonding The chalcogen, X, is in a -C(=X)- group Chalcogen bonded directly to ring carbon of the thiazole ring Nitrogen attached directly to the thiazole ring by nonionic bonding Nitrogen bonded directly to a -C(=X)- group, wherein X is chalcogen The chalcogen, X, is in a -C(=X)- group The chalcogen, X, is in a -C(=X)- group Polycyclo ring system having the oxazole ring as one of the cyclos Chalcogen bonded directly at 5-position of the oxazole ring Nitrogen bonded directly to ring carbon of the oxazole ring Cyano or -C(=X)-, wherein X is chalcogen, attached directly or indirectly to the oxazole ring by nonionic bonding Additional polycyclo heterocyclic ring system containing The -C(=X)- group is bonded directly to the thiazole ring One double bond between the ring members of the oxazole ring Nitrogen attached directly at 2-position by nonionic bonding and sulfur bonded directly to the nitrogen Nitrogen attached directly to diazine ring by nonionic bonding Additional hetero ring which is unsaturated Plural -C(=X)- groups, wherein X is chalcogen, bonded directly to the six membered hetero ring Plural acyclic nitrogens bonded directly to the same carbon or single bonded directly to each other Plural acyclic nitrogens bonded directly to the same carbon or single bonded directly to each other |
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