Assay methods involving ouabain
Patent 5164296 Issued on November 17, 1992. Estimated Expiration Date: 
August 31, 2010. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
August 31, 2010. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesHeterogeneous immunoassay for digoxin using ouabain as a separation means Method for measuring the plasma levels of an inhibitor of (Na+ +K.sup. + Isolation and purification of a digitalis-like factor Patent #: 4780314 Inventors
AssigneeApplicationNo. 575714 filed on 08/31/1990US Classes:435/7.24, Leukocyte (e.g., lymphocyte, granulocyte, monocyte, etc.)435/7.1, Involving antigen-antibody binding, specific binding protein assay or specific ligand-receptor binding assay435/7.21, Animal cell435/7.25, Erythrocyte436/93, Hetero-O (e.g., ascorbic acid, etc.)436/519, Carrier is a biological cell or cell fragment436/815, TEST FOR NAMED COMPOUND OR CLASS OF COMPOUNDS436/822IDENTIFIED HAPTENExaminersPrimary: Rosen, SamAttorney, Agent or FirmInternational ClassesC12Q 001/00G01N 033/53 AbstractMethods for diagnosing pre-hypertension, hypertension, congestive cardiomyopathy, renal failure, salt-sensitivity and adenomas and endocrine cell hyperplasias are disclosed. Also disclosed are methods for monitoring hypertension therapy, congestive cardiomyopathy therapy, renal failure therapy and adenoma and endocrine call hyperplasia therapy. These methods involve using an antibody having binding specificity to ouabain to immunologically measure the level of human ouabain in body fluid or tissue of a subject. Additionally, methods for treating a hypertensive subject by inducing passive or active immunity to human ouabain in the subject are disclosed, along with an antibody having binding specificity for ouabain.Other References
Field of SearchLeukocyte (e.g., lymphocyte, granulocyte, monocyte, etc.)Involving antigen-antibody binding, specific binding protein assay or specific ligand-receptor binding assay Heterogeneous or solid phase assay system (e.g., ELISA, etc.) Competitive assay Animal cell Erythrocyte INVOLVING AN INSOLUBLE CARRIER FOR IMMOBILIZING IMMUNOCHEMICALS TEST FOR NAMED COMPOUND OR CLASS OF COMPOUNDS IDENTIFIED HAPTEN Hetero-O (e.g., ascorbic acid, etc.) |
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