U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Method of preparing controlled-release preparations for biologically active materials and resulting compositions

Patent 5151272 Issued on September 29, 1992. Estimated Expiration Date: Icon_subject June 18, 2010. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Method of enhancing the administration of pharmalogically active agents
Patent #: 4073943
Issued on: 02/14/1978
Inventor: Wretlind ,   et al.

Bile acid emulsions
Patent #: 4115313
Issued on: 09/19/1978
Inventor: Lyon ,   et al.

Method of preparing a controlled-release pharmaceutical preparation, and resulting composition
Patent #: 4145410
Issued on: 03/20/1979
Inventor: Sears

Compositions containing aqueous dispersions of lipid spheres
Patent #: 4217344
Issued on: 08/12/1980
Inventor: Vanlerberghe ,   et al.

Method of encapsulating biologically active materials in lipid vesicles
Patent #: 4235871
Issued on: 11/25/1980
Inventor: Papahadjopoulos ,   et al.

Method of encapsulating biologically active materials in lipid vesicles
Patent #: 4241046
Issued on: 12/23/1980
Inventor: Papahadjopoulos ,   et al.

Solid formulations containing pheromones and method of using same
Patent #: 4323556
Issued on: 04/06/1982
Inventor: Dal Moro ,   et al.

Magnetically-localizable, biodegradable lipid microspheres
Patent #: 4331654
Issued on: 05/25/1982
Inventor: Morris

Lipid membrane drug delivery Patent #: 4377567
Issued on: 03/22/1983
Inventor: Geho

Inventors

Application

No. 540441 filed on 06/18/1990

US Classes:

424/450, Liposomes264/4.1, Liquid encapsulation utilizing an emulsion or dispersion to form a solid-walled microcapsule (includes liposome)424/45, Organic pressurized fluid424/84, BAITS, ATTRACTANTS, OR LURES (NON-FOOD)424/498, Containing waxes, higher fatty acids, higher fatty alcohols, or derivatives thereof424/501, Contains solid synthetic resin428/402.2, Microcapsule with fluid core (includes liposome)436/829, LIPOSOMES (E.G., ENCAPSULATION, ETC.)514/963, Microcapsule-sustained or differential release514/965, Discrete particles in supporting matrix514/966, RECTAL514/974CONTAINING DESIGNATED INGREDIENT TO REDUCE NOXIOUS EFFECTS OF ACTIVE INGREDIENT (E.G., TASTE MASKING, ODOR REDUCING, ETC.)

Examiners

Primary: Lovering, Richard D.

Attorney, Agent or Firm

Foreign Patent References

  • 0041772 EP. 05/13/1981
  • 65-26837 JP. 11/13/1965
  • 2069133 GB 08/13/1981

International Classes

A61K 009/127
A61K 037/22
B01J 013/06

Foreign Application Priority Data

1982-11-26 SE

Abstract

A method and product for preparing a controlled-release composition are provided. The method comprises formation of a mixture containing at least one amphiphilic substance capable of forming a liquid crystalline phase, in contact with a liquid selected from the group consisting of water, glycerol, ethylene glycol, propylene glycol and mixtures thereof. The method includes a step of providing in such mixture a bioactive material. Preferred controlled-release compositions include an alkylbetaine zwitterionic surfactant therein.

Other References

  • Gregoriadis: "The Carrier Potential of Liposomes in Biology and Medicine", The New England Journal of Medicine, vol. 295, No. 13, pp. 704-710, Sep. 23, 1976
  • F. Gstirner, Grundstoffe und Verfahren der Arzneibereitung, Ferdinand Enke Verlag, Stuttgart, 1960, pp. 454-455
  • S. G. Frank, Acta Pharm. Suec. 13, 41-42 (1976)
  • First page from The Journal of Physical Chemistry, 1988 92, 2261
  • Lindstrom et al "Aqueous Lipid Phases of Relevance to Intestinal Fat Digestion and Absorption", Lipids, vol. 16, No. 10, Oct. 1981, pp. 749-754
  • Svard et al "Micelles, Vesicles and Liquid Crystals in the Monoolein--Sodium Taurocholate--Water System"
  • Ulmius et al "Molecular Organization in the Liquid-Crystalline Phases of Lecithin--Sodium Cholate--Water Systems . . . " Biochemistry, 1982, 21, 1553-1560
  • Gutman et al "31 and 2 H NMR Studies . . . ", Surfactants in Solution, vol. 1, Edited by K. L. Mittal et al., Plenum Publ. Corp. (1984) pp. 143-15
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