U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Misuse-resistive transdermal opioid dosage form

Patent 5149538 Issued on September 22, 1992. Estimated Expiration Date: Icon_subject June 14, 2011. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Medical bandage
Patent #: 3996934
Issued on: 12/14/1976
Inventor: Zaffaroni

Method of administering narcotic antagonists and analgesics and novel dosage forms containing same
Patent #: 4464378
Issued on: 08/07/1984
Inventor: Hussain

Transdermal therapeutic systems for the administration of naloxone, naltrexone and nalbuphine
Patent #: 4573995
Issued on: 03/04/1986
Inventor: Chen ,   et al.

Transdermal administration of fentanyl and device therefor
Patent #: 4588580
Issued on: 05/13/1986
Inventor: Gale ,   et al.

Trandermal delivery of opioids
Patent #: 4626539
Issued on: 12/02/1986
Inventor: Aungst ,   et al.

Transdermal absorption dosage unit for narcotic analgesics and antagonists and process for administration
Patent #: 4806341
Issued on: 02/21/1989
Inventor: Chien ,   et al.

User-activated transdermal therapeutic system
Patent #: 4917676
Issued on: 04/17/1990
Inventor: Heiber, et al.

Treating opiate dependence Patent #: 4935428
Issued on: 06/19/1990
Inventor: Lewis

Inventors

Assignee

Application

No. 716037 filed on 06/14/1991

US Classes:

424/449, Transdermal or percutaneous424/484, Matrices424/486Synthetic polymer

Examiners

Primary: Page, Thurman K.
Assistant: Levy, Neil S.

Attorney, Agent or Firm

Foreign Patent References

  • 0368409 EP. 05/13/1990
  • 9004965 WO. 05/13/1990

International Classes

A61K 009/70
A61K 031/485

Abstract

A misuse-resistive dosage form for the transdermal delivery of opioid comprises, in combination, 1) one or more opioid permeable to the skin, 2) delivery means permeable to said opioid, 3) one or more antagonist for said opioid releasable upon ingestion or solvent immersion, and 4) impermeable barrier means separating said opioid and said antagonist.

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