Pyrimidinyl tetrahydrofurans

Patent 5145960 Issued on September 8, 1992. Estimated Expiration Date:

August 7, 2011. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Abstract Claims Description Full Text

Patent References

5-substituted-2',3'-dideoxycytidine compounds with anti-HTLV-III activity
Patent #: 4788181
Issued on: 11/29/1988
Inventor: Driscoll , et al.

Purinyl cyclobutanes
Patent #: 4855466
Issued on: 08/08/1989
Inventor: Zahler , et al.

Purinyl and pyrimidinyl cyclobutanes and their use as antiviral agents
Patent #: 4918075
Issued on: 04/17/1990
Inventor: Zahler, et al.

Purinyl tetrahydrofurans Patent #: 5059690
Issued on: 10/22/1991
Inventor: Zahler, et al.

Inventors

Assignee

E. R. Squibb & Sons, Inc.

Application

No. 741861 filed on 08/07/1991

US Classes:

544/310, Additional hetero ring which is unsaturated544/244, Polycyclo ring system having the diazine ring as one of the cyclos544/313, Halogen attached directly to the diazine ring by nonionic bonding544/314, Additional chalcogen attached directly or indirectly to the diazine ring by nonionic bonding544/317The nitrogen is bonded directly at 4- or 6-position

Examiners

Primary: Tsang, Cecilia J.

Attorney, Agent or Firm

Davis; Stephen B.

Foreign Patent References

182315 EP. 05/24/1986
285884 EP. 10/24/1988
291917 EP. 11/24/1988
335355 EP. 10/24/1989
391411 EP. 10/24/1990
57-146798 JP. 09/24/1982
8807532 WO. 10/24/1988
2021582 GB. 12/24/1979

International Classes

A61K 031/505
C07D 239/02
C07D 405/04

Abstract

Antiviral activity is exhibited by compounds having the formula ##STR1## and pharmaceutically acceptable salts thereof wherein R1 is a pyrimidine base or an analog thereof and R2 and R3 are independently hydrogen, --PO3 H2 or ##STR2## wherein X7 is hydrogen, alkyl, substituted alkyl or aryl.

Other References

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