U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Surface modified drug nanoparticles

Patent 5145684 Issued on September 8, 1992. Estimated Expiration Date: Icon_subject January 25, 2011. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

2671750

Injectable compositions, nanoparticles useful therein, and process of manufacturing same
Patent #: 4107288
Issued on: 08/15/1978
Inventor: Oppenheim ,   et al.

Process for the preparation of activated pharmaceutical compositions
Patent #: 4540602
Issued on: 09/10/1985
Inventor: Motoyama ,   et al.

Method for making uniformly sized particles from water-insoluble organic compounds
Patent #: 4826689
Issued on: 05/02/1989
Inventor: Violanto

Biocidal fine powder and a suspension containing the same Patent #: 4851421
Issued on: 07/25/1989
Inventor: Iwasaki ,   et al.

Inventors

Assignee

Application

No. 647105 filed on 01/25/1991

US Classes:

424/489, Particulate form (e.g., powders, granules, beads, microcapsules, and pellets)424/495, Ethyl cellulose424/499Contains proteins or derivative or polysaccharides or derivative

Examiners

Primary: Page, Thurman K.
Assistant: Benston, William E. Jr.

Attorney, Agent or Firm

Foreign Patent References

  • 411629 EP. 02/12/1991
  • 2282330 JP. 11/12/1990
  • 2185397 GB. 07/12/1987
  • 2200048 GB. 07/12/1988

International Class

A61K 009/14

Abstract

Dispersible particles consisting essentially of a crystalline drug substance having a surface modifier adsorbed on the surface thereof in an amount sufficient to maintain an effective average particle size of less than about 400 nm, methods for the preparation of such particles and dispersions containing the particles. Pharmaceutical compositions containing the particles exhibit unexpected bioavailability and are useful in methods of treating mammals.

Other References

  • Lachman et al., "the Theory and Practice of Industrial Pharmacy", Chapter 2, Milling (1986)
  • Remington's Pharmaceutical Sciences 17th Edition, Chapter 20, Schott, H., "Colloidal Dispersions
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