U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Fluorescene polarization immunoassay for tetrahydrocannabinoids

Patent 5144030 Issued on September 1, 1992. Estimated Expiration Date: Icon_subject September 1, 2009. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

2,8-Disubtituted-10-hydroxy-5,5-dimethyl-1,2,3,4-tetrahydro-5H-[1]be nzopyrano[4,3-c]pyridine
Patent #: 4152327
Issued on: 05/01/1979
Inventor: Zaugg ,   et al.

(8-Substituted-10-hydroxy-5,5-dimethyl-1,2 ,3,4-tetrahydro-5H-(1)benzopyrano(4,3-C)pyridin-2-yl)acetyl ureas and derivatives
Patent #: 4172943
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Inventor: Zaugg ,   et al.

Malate dehydrogenase conjugates for enzyme immunoassays
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Specific binding assay method and reagent means
Patent #: 4205952
Issued on: 06/03/1980
Inventor: Cais

Fluorescent labeling reagents containing the fluorescein and eosin chromophores
Patent #: 4213904
Issued on: 07/22/1980
Inventor: Haugland

Double receptor fluorescent immunoassay
Patent #: 4255329
Issued on: 03/10/1981
Inventor: Ullman

Immunological methods for removing species from the blood circulatory system and devices therefor
Patent #: 4375414
Issued on: 03/01/1983
Inventor: Strahilevitz

Fluorescent polarization immunoassay utilizing substituted triazinylaminofluoresceins
Patent #: 4420568
Issued on: 12/13/1983
Inventor: Wang ,   et al.

Radioimmunoassay for cannabinoids
Patent #: 4438207
Issued on: 03/20/1984
Inventor: Fahrenholtz ,   et al.

Substituted carboxyfluoresceins
Patent #: 4476229
Issued on: 10/09/1984
Inventor: Fino ,   et al.

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Inventors

Application

No. 366266 filed on 06/12/1989

US Classes:

546/89, Ring oxygen in the tricyclo ring system549/390, Dibenzo(b,d)pyrans (including hydrogenated)549/391Plural chalcogens bonded directly to the tricyclo ring system

Examiners

Primary: Ivy, C. Warren
Assistant: Covington, Raymond

Attorney, Agent or Firm

Foreign Patent References

  • 0191640 EP. 08/13/1986

International Classes

C07D 491/16
C07D 311/80

Abstract

This disclosure related to a method and reagents for determining tetrahydrocannabinoids (THC) and THC metabolites in a biological fluid such as urine. In particular, this disclosure relates to a fluorescence polarization immunoassay procedure for determining the presence of THC and to a novel class of tracer compounds employed as reagents in such procedures. The procedure described also provides for novel wash reagent for a THC fluorescence polarization assay.

Other References

  • Pitt: J of the Amer. Chem. Soc. 97(13) p. 3798-3802, 1975
  • Lander: Chemical Abstracts 84: 105813e (1976)
  • Apsimon: Chemical Abstracts 98: 16868y (1983)
  • Wilson: Chemical Abstracts 91: 49274k (1979
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