Method and composition for controlled delivery of biologically active agents

Patent 5143934 Issued on September 1, 1992. Estimated Expiration Date:

October 20, 2009. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Abstract Claims Description Full Text

Patent References

2196322

Composition for periodontal administration
Patent #: 4568535
Issued on: 02/04/1986
Inventor: Loesche

Medicated suppository Patent #: 4698359
Issued on: 10/06/1987
Inventor: Niederer , et al.

Inventors

Application

No. 424416 filed on 10/20/1989

US Classes:

514/396, Imidazoles424/423, Surgical implant or material424/435, Mouth424/484, Matrices424/776, Containing or obtained from a seed or nut514/943, Higher fatty acid or derivative containing514/944, GEL514/964SUSTAINED OR DIFFERENTIAL RELEASE TYPE

Examiners

Primary: Griffin, Ronald W.
Assistant: Gitomer, Ralph

Attorney, Agent or Firm

Seidel, Gorda, Lavorgna & Monaco

Foreign Patent References

0244118 EP. 11/13/1987
0126751 EP. 05/13/1988

International Class

A61K 031/415

Abstract

Controlled delivery of biologically active agents such as pharmaceuticals to body sites is accomplished by combination with a monoglyceride and a vegetable oil. Upon contact with an aqueous liquid, the composition forms a reverse hexagonal liquid crystalline phase matrix which releases the active agent in controlled fashion. The method of delivery is particularly useful for the treatment of periodontal disease by insertion of the liquid crystalline phase precursor composition directly into the periodontal pocket, where water from the gingival fluid induces the spontaneous in situ formation of the reverse hexagonal liquid crystalline phase matrix.

Other References

Lewkowtsch, Chemical Analysis of Oils Fats & Waxes 1898 pp. 385-389
Balmbra, R. R. Nature 222 1969 pp. 1159-1160
Goodson et al., J. Clin. Periodon. 6, 83-92 (1979)
Lindhe et al., J. Clin. Periodon. 6, 141-149 (1979)
Dunn et al., Proceed. Intern. Symp. Control Rel. Bioact. Mater. 14 259-260 (1987)
Minabe et al., J. Clin. Periodont. 16. 291-294 (1989)
Addy et al., Periodontol. 53. 693-699 (1982)
Golomb et al., J. Dent. Res. 63, 1149-1153 (1984)
Baker et al. Proceed. Intern. Symp. Control Rel. Bioact Mater. 15, 238 a-238 b (1988)
Gutman et al., Surfactants in Solution, vol. 1 (ed. K. L. Mitt and B. Lindman) Plenum Pub. Corp., 1984, p. 143-152
Lindstrom et al., Lipids, 16, 749-754 (1981)
Landh et al., "Water System-A Drug Delivery Sytem". Abstract, Bioscience, Lund, Sweden (Apr. 23-26, 1989)
Landh et al., "Aqueous Dispersions of the Cubic Liquid Crystalline Phase in the Monoclein-Lectin Water System-A Drug Delivery System" Abstract, Bioscience, Lund, Sweden (Apr. 23-26, 1989)
Landh et al., (Untitled) Abstract, Abo, Finland (Jun. 10-11, 1989