Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
Patent 5143854 Issued on September 1, 1992. Estimated Expiration Date: March 7, 2010. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
436/518, INVOLVING AN INSOLUBLE CARRIER FOR IMMOBILIZING IMMUNOCHEMICALS435/7.92, Heterogeneous or solid phase assay system (e.g., ELISA, etc.)435/7.94, Sandwich assay435/7.95, Indirect assay435/961, INCLUDING A STEP OF FORMING, RELEASING, OR EXPOSING THE ANTIGEN OR FORMING THE HAPTEN-IMMUNOGENIC CARRIER COMPLEX OR THE ANTIGEN, PER SE435/968, HIGH ENERGY SUBSTRATES (E.G., FLUORESCENT, CHEMILUMINESCENT, RADIOACTIVE, ETC.)435/973, SIMULTANEOUS DETERMINATION OF MORE THAN ONE ANALYTE436/527, Glass or silica436/528, Carrier is organic436/807, APPARATUS INCLUDED IN PROCESS CLAIM (E.G., PHYSICAL SUPPORT STRUCTURES, ETC.)530/333, Synthesis of peptides530/334, Polymer supported synthesis, e.g., solid phase synthesis, Merrifield synthesis, etc.530/335, Protecting or removing protective groups, e.g., carboxyl group protection, etc.530/336, Of side chain or sulfur containing group530/337Of amino group
Polypeptide arrays can be synthesized on a substrate by attaching photoremovable groups to the surface of a substrate, exposing selected regions of the substrate to light to activate those regions, attaching an amino acid monomer with a photoremovable group to the activated regions, and repeating the steps of activation and attachment until polypeptides of the desired length and sequences are synthesized. The resulting array can be used to determine which peptides on the array can bind to a receptor.
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March 7, 2010. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
