U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Stable ascorbic acid compositions

Patent 5140043 Issued on August 18, 1992. Estimated Expiration Date: Icon_subject August 18, 2009. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

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Inventors

Assignee

Application

No. 339488 filed on 04/17/1989

US Classes:

514/474Ascorbic acid or derivative (e.g., vitamin C, etc.)

Examiners

Primary: Schenkman, Leonard

Attorney, Agent or Firm

Foreign Patent References

  • 63-37087 JP. 08/12/1989

International Class

A61K 031/34

Abstract

Stable topical aqueous compositions are provided containing a concentration of L-ascorbic acid above about 1% (W/V) and maintaining a pH below about 3.5.

Other References

  • Chemical Abstracts, 110:198950r, (1989), (Pub. Nov. 1988)
  • Lewin, Sherry, Vitamin C: Its Molecular Biology and Medical Potential, Academic Press, 1976, pp. 4-222
  • E. Meucci et al., Ascorbic Acid Stability in Aqueous Solutions, Acta Vitaminol. Enzymol., 1985, 7(3-4), 147-154
  • Ciminera, J. et al., Stable Ascorbic Solution for Parenteral Use, Journal of the American Pharmaceutical Association, (1946), pp. 363-365
  • H. Schaefer et al., Skin Permeability, Springer-Velag, 1982, pp. 739-740
  • Karl-Josef Kunert et al., The Effect of Vitamin C on in vivo Lipid Peroxidation in Guinea Pigs as Measured by Pentane and Ethane Production, Lipids, vol. 18, No. 4, (1983), pp. 271-274
  • Takashima et al., Ascorbic Acid Esters and Skin Pigmentation, American Perfumer and Cosmetics, vol. 86, No. 7, Jul. 1971
  • Sasha Englard et al., The Biochemical Functions of Ascorbic Acid, Annual Reviews Inc., 1986, pp. 365-406
  • Imai, Yoshio et al., The Antiscorbutic Activity of L-Ascorbic Acid Phosphate Given Orally and Percutaneously in Guinea Pigs, The Japanese Journal of Pharmacology, vol. 17, No. 2, Jun. 1967, pp. 317-324
  • Ascorbic Acid, Merck Service Bulletin, 194
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