Patent 5140043 Issued on August 18, 1992. Estimated Expiration Date: August 18, 2009. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
Stable topical aqueous compositions are provided containing a concentration of L-ascorbic acid above about 1% (W/V) and maintaining a pH below about 3.5.
Other References
Chemical Abstracts, 110:198950r, (1989), (Pub. Nov. 1988)
Lewin, Sherry, Vitamin C: Its Molecular Biology and Medical Potential, Academic Press, 1976, pp. 4-222
E. Meucci et al., Ascorbic Acid Stability in Aqueous Solutions, Acta Vitaminol. Enzymol., 1985, 7(3-4), 147-154
Ciminera, J. et al., Stable Ascorbic Solution for Parenteral Use, Journal of the American Pharmaceutical Association, (1946), pp. 363-365
H. Schaefer et al., Skin Permeability, Springer-Velag, 1982, pp. 739-740
Karl-Josef Kunert et al., The Effect of Vitamin C on in vivo Lipid Peroxidation in Guinea Pigs as Measured by Pentane and Ethane Production, Lipids, vol. 18, No. 4, (1983), pp. 271-274
Takashima et al., Ascorbic Acid Esters and Skin Pigmentation, American Perfumer and Cosmetics, vol. 86, No. 7, Jul. 1971
Sasha Englard et al., The Biochemical Functions of Ascorbic Acid, Annual Reviews Inc., 1986, pp. 365-406
Imai, Yoshio et al., The Antiscorbutic Activity of L-Ascorbic Acid Phosphate Given Orally and Percutaneously in Guinea Pigs, The Japanese Journal of Pharmacology, vol. 17, No. 2, Jun. 1967, pp. 317-324