Synthesis of sialosides
Patent 5138044 Issued on August 11, 1992. Estimated Expiration Date: 
August 13, 2010. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
August 13, 2010. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesSialic acid derivative and process for preparing the same Sialic acid derivatives Process for producing sialic acid derivatives 3-phenylthiosialic acid derivative, sialic acid-containing oligosaccharide derivative and process for preparing these compounds Patent #: 4935506 InventorAssigneeApplicationNo. 566682 filed on 08/13/1990US Classes:536/18.5, Processes536/4.1, O- or S- Glycosides536/17.1, Boron, phosphorus, heavy metal or aluminum containing536/17.5, Sulfur containing (e.g., methylthiolincosaminide, etc.)536/54, Sulfur containing536/55.2, Glucosamine containing536/55.3ProcessesExaminersPrimary: Brown, Johnnie R.Assistant: White, Everett Attorney, Agent or FirmForeign Patent References
International ClassesC07G 003/00C07H 005/04 C07H 005/10 AbstractReaction schemes for carrying out a variety of chemical synthesis are disclosed. The reactions produce -(X)-sialosides wherein X is O, S, N or another compatible electron donating atom or molecular moiety. The reaction schemes include a relatively small number of steps to provide a yield with a relatively small amount of undesired ଲ-configuration product. Compounds synthesized are encompassed by the following general structural formula I. ##STR1## wherein R, R' and R" are each independently H, CH3, acetyl, or a disaccharide which is preferably lactose. |
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