Extract and pharmaceutical composition for treatment of calcium oxalate stone disease
January 16, 2011. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesProcess for removing calcium oxalate scale 2,4-Dioxo-4-substituted-1-butanoic acid derivatives useful in treating urinary tract calcium oxalate lithiasis 2,4-Dioxo-4-substituted-1-butanoic acid derivatives useful in treating urinary tract calcium oxalate lithiasis Method and kit for diagnosing a patient's proneness to develop calcium oxalate kidney stones 2,4-Dioxo-4-substituted-1-butaoic acid derivatives useful in treating urinary track calcium oxalate lithiasis 4-Hydroxy-5-substituted-3-(2H)-isothiazolone-1,1-dioxide derivatives useful in treating urinary tract calcium oxalate lithiasis 4-Hydroxy-5-substituted-3(2H)-isothiazolone-1,1-dioxide derivatives useful in treating urinary tract calcium oxalate lithiasis (4'-Biphenylyloxy and-thio-oxy)-3-hydroxy-3-pyrroline-2,5-diones and a method of treating calcium oxalate renal lithiasis therewith Purification of solutions of sodium aluminate in the Bayer cycle by the removal of sodium oxalate Pharmaceutical products, calcium mixed salts of polymeric, anionic carboxylic acids and/or their esters of sulfuric acid, and methods for their preparation and use InventorAssigneeApplicationNo. 641763 filed on 01/16/1991US Classes:424/765, Containing or obtained from Roseaceae (e.g., rose, hawthorn, meadowsweet, strawberry, raspberry, blackberry, apple, etc.)514/891KIDNEY STONEExaminersPrimary: Rollins, John W.Attorney, Agent or FirmInternational ClassA61K 035/78AbstractAn extract for the treatment of calcium oxalate kidney stone disease which can be extracted and purified from leaves of the plant Eriobotrya japonica is disclosed. The extract has the following characteristics: inhibits calcium oxalate crystal growth in vitro, inhibits renal calcium oxalate crystal deposition in rats which are fed ethylene glycol, causes rats which are fed ethylene glycol and said extract to excrete less oxalate in their urine as compared to rats which are fed ethylene glycol without said extract, shows little or no loss in activity when exposed to an aqueous solution of pH 1.5 for 14 hours, shows increased activity when exposed to an aqueous solution of pH 12.7 for 15 hours, is polyanionic, is stable when heated in an aqueous solution (at pH of extract) at 98° C. for 3 hours, water-soluble, insoluble in heptane, hexane, chloroform/methanol mix, diethyl ether, and ethanol/aqueous mix, binds to DEAE-A-25 Sephadex at pH 8.6 and is eluted from the DEAE-A-25 Sephadex with 2 M NaCl. The present invention is also directed to a method for the treatment of calcium oxalate stone disease wherein the extract is administered, preferably for a prolonged period of time, to a patient suffering from or prone to calcium oxalate stone disease.Other References
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