U.S. patents available from 1976 to present.
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Method and a pharmaceutical composition for the inhibition of angiogenesis

Patent 5135919 Issued on August 4, 1992. Estimated Expiration Date: Icon_subject August 4, 2009. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

2803586

2844512

3232833

Pharmaceutical preparations containing cyclodextrin derivatives Patent #: 4727064
Issued on: 02/23/1988
Inventor: Pitha

Inventors

Assignee

Application

No. 173305 filed on 03/25/1988

US Classes:

514/56, Heparin or derivative514/24, S-glycoside514/58, Dextrin or derivative514/475The hetero ring is three-membered

Examiners

Primary: Griffin, Ronald W.
Assistant: Webber, Pamela S.

Attorney, Agent or Firm

International Classes

A61K 031/715
A61K 031/70

Abstract

Fumagillin and its salts have an angiogenesis inhibiting activity and are useful for prophylaxis and treatment of diseases induced by abnormally stimulated neovascularization. The invention also provides certain pharmaceutical compositions comprising fumagillin or its salt, and an agent which potentiates angiogenesis inhibition such as heparin and sulfated cyclodextrins such as beta-cyclodextrin tetradecasulfate.

Other References

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  • Folkman, et al. Science 230:1375-1378 (1985)
  • Folkman, et al., Journal of Cell Biology, vol. 107, No. 6, part 3, p. 579a, Abstract No. 3277 (1988)
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  • DiPaolo, et al. (Carcinolytic Activity of Fumagillin) Antibiotics Annual; 541-546 (1958-1959)
  • The Merck Index Tenth Edition; 611-612 (1983
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