Patent 5130144 Issued on July 14, 1992. Estimated Expiration Date: March 22, 2011. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
Monoclonal antibodies that recognize a stage-specifc antigen on immature human marrow cells are provided. These antibodies are useful in methods of isolating cell suspensions from human blood and marrow that can be employed in bone marror transplantation. Cell suspensions containing human pluripotent lympho-hematopoietic stem cells are also provided, as well as theraputic methods employing the cell suspensions.
Other References
Preschel et al., "M7 Cluster Rept: CD34", ed. Knapp, at the Fourth Int'l Workshop and Conference on Human Leucocyte (1989), p. 817
Civin et al., "M7.1 Rept on the CD34 Cluster Workshop", ed. Knapp, at the Fourth Int'l Workshop and Conference on Human Leucocyte (1989), p. 818
Lansdrop et al., "M7.2 CD34 Epitopes", ed. Knapp, at the Fourth Int'l Workshop and Conference on Human Leucocyte (1989), p. 826
Molgaard et al., "M7.3 Molecular Characterization of Human and Murine CD34", ed, Knapp, at the Fourth Int'l Workshop and Conference on Human Leucocyte (1989), p. 827
Civin et al., "Antigenic Analysis of Hematopoiesis III. A Hematopoietic Progenitor Cell Surface Antigen Defined by a Monoclonal Antibody Raised Against KG-1a Cells", J. Immunology 133:157-165 (1984)
Civin et al., "Cell Surface Antigens of Human Myeloid Cells", (1982) Exp. Hematol. 10:129 (abstract)
Civin et al., "Characterization of Four Monoclonal Antibodies Reactive with Human Cell Subsets", Blood, 60(5):95a (abstract)
Civin et al., "Cell Surface Antigens by Four Monoclonal Antibodies Raised Against KG-1a Cells", Hybridoma, 2:125a (abstract)
Brovall et al., "Identification and Partially Characterization of Two Human Potential Hematopoietic Differentiation Antigens" Exp. Hematol. 11:(Supp.) 199 (abstract)
Civin et al., "Diagnostic and Prognostic Utility of Cell Surface Markers In Acute Non-Lymphocytic Leukemia" (ANLL), Exp. Hematol. 11:(Supp.)84
Strauss et al., "MY-10, A Human Hematopoietic Progenitor Cell Surface Antigen Identified by a Monoclonal Antibody" Exp. Hematol. 11:205 (abstract)
Strauss, et al. "MY-10 Antigen is Lost at the CFU-E Stage During Erythroid Progenitor Cell Maturation", (1984) I.S.E.H. (Abstract)
Leary, et al., "Single Cell Origin of Human Multilineage Colonies", (1984) I.S.E.H. (Abstract)
Bodger, et al., "Surface Antigenic Determinants on Human Pluripotent and Unipotent Hematopoietic Progenitor Cells", (1983) Blood, 61:1006-1010
Bodger, et al., "A Monoclonal Antibody Specific for Immature Human Hemopoietic Cells and T Lineage Cells", (1981) J. Immunology, 127:2269-2274
Nadler et al., "Diagnosis and Treatment of Human Leukemias and Lymphomas Utilizing Monoclonal Antibodies" Prog. Hematol., 12:187-225
Winchester, et al., "Expressin of Ia-like antigen molecules on human granulocytes during early phases of differentiation", Proc. Natl. Acad. Sci. USA 74:4012-4016 (1977)
Stashenko, et al., "Characterization of a Human B Lymphocyte-Specific Antigen" J. Immunology, 125:1678-1685 (1980)
Reinherz, et al., "Regulation of the Immune Response--Inducer and Suppresoor T-Lymphocyte Subsets in Human Beings" (1980) N. Engl. J. Med. 303:370
Ritz, et al., "A Monoclonal Antibody to Human Acute Lymphoblastic Leukaemia Antigen" Nature 283:583-58
March 22, 2011. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
