Patent ReferencesMethod for reducing sensitization or irritation in transdermal drug delivery and means therefor Transdermal estrogen/progestin dosage unit, system and process Prevention of contact allergy by coadministration of a corticosteroid with a sensitizing drug Transdermal estrogen/progestin dosage unit, system and process Patent #: 5023084 InventorsAssigneeApplicationNo. 475609 filed on 02/06/1990US Classes:424/449, Transdermal or percutaneous424/448, Pressure sensitive adhesive means604/307Adhesively attachable to bodyExaminersPrimary: Page, Thurman K.Assistant: Horne, Leon R. Attorney, Agent or FirmInternational ClassA61F 013/00Foreign Application Priority Data1989-02-09 DEAbstractThe present invention relates to a therapeutic system for the transdermal or transmucous administration of active substances via an impermeable backing layer, a reservoir which at least partially comprises active substance, is double-layered and consists of separate parts, and a protective layer, whereby the two reservoir members(a) are positioned substantially parallely on top of each other,(b) are separated from each other by a removable intermediate layer being impermeable to the active substances of said reservoir members,(c) either comprise active substance or auxiliary agents or both at concentrations not corresponding to the distribution equilibrium. | |