U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Pulsed field capillary electrophoresis

Patent 5122248 Issued on June 16, 1992. Estimated Expiration Date: Icon_subject May 18, 2010. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

High performance microcapillary gel electrophoresis
Patent #: 4865706
Issued on: 09/12/1989
Inventor: Karger ,   et al.

Velocity modulated capillary electrophoresis analysis system
Patent #: 4909919
Issued on: 03/20/1990
Inventor: Morris, et al.

Fractionation and sample loading by cassette in capillary electrophoresis
Patent #: 4911807
Issued on: 03/27/1990
Inventor: Burd

Process for preparation of electrophoresis
Patent #: 4985128
Issued on: 01/15/1991
Inventor: Ebersole, et al.

Flow-rate-controlled surface-charge coating for capillary electrophoresis Patent #: 5015350
Issued on: 05/14/1991
Inventor: Wiktorowicz

Inventors

Assignee

Application

No. 525532 filed on 05/18/1990

US Classes:

204/453, With injection204/455, Using gel-filled capillary204/458, Plural rapid changes in direction of electric field (at least 1,000 times total and at more than 1/sec) (e.g., pulsed field, etc.)204/604, With injector204/605, Gel filled204/609Plural rapid changes in direction of electric field (at least 1,000 times total and at more than 1/sec) (e.g., pulsed field, etc.)

Examiners

Primary: Niebling, John F.
Assistant: Koestner, Caroline

Attorney, Agent or Firm

International Classes

C25B 001/00
C25B 007/00
B01D 061/42

Abstract

Apparatus and method for conducting electrophoresis in a capillary tube under the influence of a pulsed electric field. Apparatus for separating and detecting molecular species of a sample in a conductive medium includes a capillary tube for containing conductive medium, means for introducing a sample into a conductive medium-filled capillary tube, means for applying a pulsed electric field across the conductive medium-filled capillary tube between its ends, and means for detecting constituent molecular species of a sample in a conductive medium-filled capillary tube as they traverse the tube. A method for separating and detecting molecular species of a sample in a conductive medium includes the steps of introducing the sample into a capillary tube filled with conductive medium, applying a pulsed electric field of up to 500 volts/centimeter between the ends of the capillary, and detecting the constituent molecular species of the sample as they traverse the capillary.

Other References

  • Avdalovic, N. and Furst, A.: "An instrument for separating fragments of chromosomal DNA", American Biotech Laboratory, 26-34, May (1989)
  • Cantor, C., Smith, C. and Mathew, M.: "Pulsed-field gel Electrophoresis of very large DNA molecules", Ann. Rev. Biophys. Biophys. Chem. 17; 287 (1988)
  • Dawkins, H. J. S.: "Large DNA separation using field alternation agar gel electrophoresis", Journal of Chromatography, 492 (1989) 615-639, Elsevier Science Publishers B.V., Amsterda
PatentsPlus Images
Enhanced PDF formats
loading...
PatentsPlus: add to cart
PatentsPlus: add to cartSearch-enhanced full patent PDF image
$9.95more info
 
Sign InRegister
Username  
Password   
forgot password?