Bone growth factors and inhibitors of bone resorption for promoting bone formation
Patent 5118667 Issued on June 2, 1992. Estimated Expiration Date: May 3, 2011. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
514/12, 25 or more peptide repeating units in known peptide chain structure514/8, Glycoprotein (carbohydrate containing)514/21Produced by or extracted from animal tissue
Bone growth factors are used to stimulate new bone formation when administered with agents that inhibit bone resorption. These therapeutic combinations result in an enhanced rate of bone formation with an increase in bone mass.
Other References
Sawchenko et al., Nature (1988) 334:615-617
Slovik et al., J. Bone & Min. Res. (1986) 1(4):377-381
Totsuka et al., Biochem. Biophys. Res. Comm. (1988) 156:335-339
Urist et al., Clin. Orthop. Rel. Res. (1982) 162:219-232
Urist et al., Proc. Natl. Acad. Sci. (1984) 81:371-375
Urist et al., Science (1983) 220:680-685
Vale et al., Nature (1986) 321:776-779
Vale et al., Recent Progress in Hormone Research (1988) 44:1-34
Yu et al., Nature (1987) 330:765-767
Bentz et al., J. Biol. Chem. (1989) 264:20805-20810
Broxmeyer et al., Proc. Natl. Acad. Sci. (1988) 85:9052-9056
Centrella et al., J. Biol. Chem. (1987) 262:2869-2874
Cheifetz et al., J. Biol. Chem. (1988) 263:17225-17228
Chenu et al., Proc. Natl. Acad. Sci. (1988) 85:5683-5687
Isgaard et al., Endocrinol. Metab. (1986) 13:E367-E372
Joyce et al., J. Cell. Biol. (1990) 110:2195-2207
Murata et al., Proc. Natl. Acad. Sci. (1988) 85:2334-2438
Noda et al., Endocrinology (1989) 124(6):2991-2994
Kiebzak et al., J. Bone Min. Res. (1988) 3:439-446
Ozkaynak et al., EMBO J. (1980) 9:2085-2093
Pfeilschifter et al., Proc. Natl. Acad. Sci. (1987) 84:2024-2028
Sampath et al., J. Biol. Chem. (1990) 265:13198-13205
Wozney, Progress in Growth Factor Research (1989) 1:267-28