Sustained release pharmaceutical composition of diltiazem

Patent 5112621 Issued on May 12, 1992. Estimated Expiration Date:

July 26, 2010. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Abstract Claims Description Full Text

Patent References

Process for preparing a sugar and starch free spray-dried vitamin C powder containing 90 percent ascorbic acid
Patent #: 4533674
Issued on: 08/06/1985
Inventor: Schmidt , et al.

Enteric coated tablet and process for making
Patent #: 4775536
Issued on: 10/04/1988
Inventor: Patell

Oral pharmaceutical composition
Patent #: 4780318
Issued on: 10/25/1988
Inventor: Appelgren , et al.

Taste-masked pharmaceutical compositions Patent #: 4800087
Issued on: 01/24/1989
Inventor: Mehta

Inventors

Assignee

Synthelabo

Application

No. 559429 filed on 07/26/1990

US Classes:

424/497, Containing solid synthetic polymers424/458, Containing discrete coated particles pellets, granules, or beads424/461, Containing polysaccharide (e.g., cellulose sugars, etc.)424/462, Containing solid synthetic polymers424/465, With claimed perfecting feature in contents (e.g., excipient, lubricant, etc.)424/480, Cellulose or derivative424/482, Containing solid synthetic polymers424/495, Ethyl cellulose427/2.16, Retarded or controlled-release layer produced (e.g., enteric)427/2.19Retarded or controlled-release layer produced (e.g., enteric)

Examiners

Primary: Page, Thurman K.
Assistant: Spear, James M.

Attorney, Agent or Firm

Fleit, Jacobson, Cohn, Price, Holman & Stern

Foreign Patent References

WO84/2843 WO. 08/12/1984

International Classes

A61K 009/16
A61K 009/58
A61K 009/62

Foreign Application Priority Data

1987-12-21 FR

Abstract

A sustained-release pharmaceutical composition which comprises microparticles comprising an active principle, said microparticles being coated with a coating mixture comprising ethyl cellulose and an acrylic resin which is a polymerizate of acrylic and methacrylic ester, having a molecular weight of at least 100,000 and comprising units of formula: ##STR1## wherein: R1 is hydrogen or methyl,R2 is methyl or ethyl,R3 is methyl; andR4 is --CH2 --CH2 N(CH3)3 Clthe resin containing 5% of trimethylammonium methacrylate chloride units by weight.