U.S. patents available from 1976 to present.
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Intermediates in the preparation of steriod 5-alpha-reductase inhibitors

Patent 5110939 Issued on May 5, 1992. Estimated Expiration Date: Icon_subject October 10, 2009. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

2846445

2846446

2897202

3644425

N-substituted-17ଲ-carbamoylandrost-4-en-3-one 5଱ reductase inhibitors
Patent #: 4191759
Issued on: 03/04/1980
Inventor: Johnston ,   et al.

Novel steroid 5଱-reductase inhibitors
Patent #: 4317817
Issued on: 03/02/1982
Inventor: Blohm ,   et al.

D-Homosteroids
Patent #: 4361578
Issued on: 11/30/1982
Inventor: Alig ,   et al.

4-Aza-17ଲ-substituted-5଱-androstan-3-one-reductase inhibitors
Patent #: 4377584
Issued on: 03/22/1983
Inventor: Rasmusson ,   et al.

Steroidic 5଱-reductase inhibitors
Patent #: 4732897
Issued on: 03/22/1988
Inventor: Cainelli ,   et al.

17ଲ-N-monosubstituted carbamoyl-4-aza-5଱-androst-1-en-3-ones which are active as testosterone 5଱-reductase inhibitors Patent #: 4760071
Issued on: 07/26/1988
Inventor: Rasmusson ,   et al.

Inventors

Assignee

Application

No. 419563 filed on 10/10/1989

US Classes:

548/250, Tetrazoles (including hydrogenated)514/284, Tetracyclo ring system having the six-membered hetero ring as one of the cyclos549/331, The spiro includes a hetero ring558/429, The ring system contains at least three cyclos560/117Tricyclo ring system in acid moiety

Examiners

Primary: Shah, Mukund J.
Assistant: Ward, E. C.

Attorney, Agent or Firm

International Classes

C07D 307/94
C07D 257/04
C07C 069/608

Abstract

Invented are 4-aza-5-alpha-8(14)-17 substituted-androsten-3-ones having an 8(14), 7(8), or 16(17) double bond, optionally also having a 1(2) double bond, pharmaceutical compositions containing the compounds, and methods of using these compounds to inhibit steroid 5-alpha-reductase.

Other References

  • Imperato-McGinley, J., et al., J. Steroid Biochem. 11:637-645 (1979
  • Hsia and Voight, J. Invest. Dermat. 62:224-227 (1973)
  • Robaire et al., J. Steroid Biochem. 8:307-310 (1977)
  • Blohm, T. R., et al., Biochem. Biophys. Res. Comm. 95:273-280 (1980)
  • Liang, T., et al., J. Steroids Biochem. 19,385-390 (1983)
  • Petrow, V., et al., Steroids 38:121-140 (1981)
  • Brooks et al., Steroids: 47:1-19 (Jan. 1986)
  • Overnell et al., J. Chem. Soc. (c) 2 pp. 378-384. (1971)
  • Frimer et al., J. Org. Chem., vol. 47, No. 14, pp. 2818-2819 (1982)
  • Baumgarth et al., Tehrahedron, vol. 31, pp. 3119-3120 (1975)
  • Brooks et al., The Prostate, vol. 9, pp. 65-75 (1986)
  • Singh et al., J. Chromatography, 137, pp. 202-205 (1977
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