Noninvasive diagnostic system for coronary artery disease
Patent 5109863 Issued on May 5, 1992. Estimated Expiration Date: May 6, 2011. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
A method and system for non-invasively detecting Coronary Artery Disease. The method comprises analyzing the diastolic heart sounds detected from a patient's chest cavity during the diastolic portion of the heart cycle in order to identify a low level auditory component associated with turbulent blood flow in partially occluded coronary arteries. These diastolic heart sounds are modeled using advanced signal processing techniques such as Autoregressive (AR), Autoregressive Moving Averaging (ARMA) and Eigenvector methods, so that the presence of such an auditory component may be reliably indicated even under high noise conditions. The system includes an acoustic transducer, pulse sensor device, signal processor means and a diagnostic display. Additionally, the system includes a controller for automatically sequencing data collection, analysis and display stages, therefore requiring a minimum of operator interaction. The system further discloses a piezoelectric type low mass accelerometer for use as an acoustic transducer providing high sensitivity at the high frequencies necessary for detecting coronary artery disease, specifically between 300 to 1200 Hz. In addition, the system discloses a method for automatically identifying and isolating a diastolic segment of a heart sound recording through a "window" placement technique. A window is placed relative to the second heart sound and various criteria are implemented to evaluate the recording for artifacts, i.e., data due to breath sounds, stomach growls, external ambient noise.
Other References
David W. Mortara, Ph.D. Raymond E. Ideker, M.D., James J. Bailey, M.D.; Computerized Interpretation of the Electrocardiogram: Jun. 1984; Reference pp. 5-17 (James Bailey, M.D., Editor, Jun. 1984)
Akay et al., "Analysis of Diastolic Heart Sounds Before and After Angioplasty" IEEE, EMBS 10th Int'l Conf., Nov. 1988
Akay et al., "Autoregressive Modeling of Diastolic Heart Sounds", IEEE, EMBS 10th Int'l. Conf., Nov. 1988
Ortiz, M., "Acoustical Noninvasive Diagnosis of Coronary Artery Disease", Proc. of 13th Ann. NE. Bieng. Conf., 1987
Ortiz, M., "Non-Invasive Acoustical Diagnosis of Coronary Artery Disease", Thesis, May, 1987
May 6, 2011. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
