Method for production of t-butyl 3-oxobutyrates and their use
Patent 5109131 Issued on April 28, 1992. Estimated Expiration Date: April 28, 2009. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
Disclosed are an advantageous method of industrial production of tert-butyl 3-oxobutylate, which is a useful intermediate for synthesis, characterized by reacting tert-butyl alcohol with diketene in the presence of 4-(tertiary amino) pyridine, and an industrially advantageous method of producing cephalosporin compounds or pharmaceutically acceptable salts thereof, using tert-butyl 3-oxobutylate as an intermediate.
Sven-Olov Lawesson et al., "Acetoacetic Acid, Tert-butyl Ester", Organic Syntheses, vol. 42, (1962) pp. 28-29
Stephen R. Wilson et al., "The Ester Enolate Carroll Rearrangement", J. Org. Chem., vol. 49, (1984) pp. 722-72