Magnetic particles for immunoassay
Polymer filler particles with filler free coating
Binding assays employing magnetic particles Patent #: 4628037
ApplicationNo. 337511 filed on 05/30/1989
US Classes:427/2.18, En masse rotating means employed (e.g., rotating pan, tumbling)427/128, Magnetic coating427/131, Applying superposed diverse coating or coating a coated base427/214, Applying superposed diverse coatings or coating a coated base427/222, Resin base436/513, INVOLVING IGA, IGD, IGE, OR IGM436/526Magnetic
ExaminersPrimary: Kepplinger, Esther M.
Assistant: Stall, Jacintha M.
Attorney, Agent or Firm
Foreign Patent References
International ClassesA01N 001/02
AbstractThis invention provides a novel process of producing magnetically responsive polymer particles comprising polymeric core particles coated evenly with a layer of polymer containing magnetically responsive metal oxide. A wide variety of polymeric particles with sizes ranging from 1 to 100 microns can be used a core particles and transformed into magnetically responsive polymer particles. The surface of these magnetically responsive polymer particles can be coated further with another layer of functionalized polymer. These magnetically responsive polymer particles can be used for passive or covalent coupling of biological material such as antigens, antibodies, enzymes of DNA/RNA hybridization and used as solid phase for various types of immunoassays, DNA/RNA hybridization probes assays, affinity purification, cell separation and other medical, diagnostic, and industrial applications.
Field of SearchMAGNETIC BASE OR COATING
With pretreatment of base
With post-treatment of coating or coating material
Applying superposed diverse coating or coating a coated base
PARTICLES, FLAKES, OR GRANULES COATED OR ENCAPSULATED
Applying superposed diverse coatings or coating a coated base
Resin, rubber, or hardenable oil containing coating
Synthetic resin coating
Protein or derivative containing coating (e.g., casein, glue, gelatin, etc.)
With wax, bitumen, resin, or gum
Free metal or alloy containing
Iron-oxygen compound containing